Ignite Creation Date:
2025-12-25 @ 5:05 AM
Ignite Modification Date:
2025-12-26 @ 4:08 AM
Study NCT ID:
NCT02484118
Status:
COMPLETED
Last Update Posted:
2015-12-09
First Post:
2015-02-04
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Hemodialysis Blood Flow and Urea Clearance
Sponsor:
University of British Columbia
Organization:
Study Overview
Official Title:
Examining the Effect of Blood Flow Rate on Hemodialysis Urea Clearance
Status:
COMPLETED
Status Verified Date:
2015-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study purpose is to determine whether two different hemodialysis blood flow rates each meet national dialysis standards for urea clearance. Urea is used as the primary marker of dialysis adequacy. It is an experimental study with a crossover design of minimum 38 participants. Participants will be selected from the accessible pool of end-stage renal disease clients at the Vancouver Community Dialysis Unit. The participants will dialyse at each pre-determined blood flow rate (320 mL/min and 380 mL/min) for two weeks each. Two forms of urea clearance data will be collected: one value that is routinely calculated by the dialysis machine and recorded on client treatment logs, and another that is calculated in a lab from blood samples.
Detailed Description:
Design This quasi-experimental study involves the independent variable of blood flow rate (Qb), measured in mL/min, and the dependent variable of dialysis clearance, measured by Kt/V and URR (urea reduction ratio). Control and randomization will be manifested in a crossover design, which provides the benefit of separating treatment effects from period effects (Wellek \& Blettner, 2012). Participants will be randomly assigned - by way of selecting names from an envelope - to one of two groups: A, which dialyses first at 320 mL/min; or B, at 380 mL/min. Each study period will consist of two weeks (6 sessions, 24 hours of dialysis) at each Qb. Because urea clearance is immediate, six treatments at each Qb will reflect accurate data on Kt/V and URR (Dr. John Duncan, 2014, personal communication). Although carryover effects are not of concern to this study as participants routinely dialyse three times per week, wherein urea levels naturally rise between routine treatments, a washout phase of one week between study periods will occur, as is recommended for an effective crossover design (Wellek \& Blettner, 2012).
Sample
The target and sample population are end-stage renal disease patients dialysing with an arteriovenous fistula (AVF) at the Vancouver Community Dialysis Unit. Power analysis was conducted by the Centre for Health Evaluation and Outcome Sciences (CHEOS). To ensure a Kt/V of 1.3 and URR of 70% can be estimated with a confidence interval of 95%, a minimum sample size of 34 participants is required. An additional 10% is necessary to account for attrition. Because randomization will occur with study period assignment, purposive sampling will be used to select participants from the accessible pool (estimated at 60 patients), until 38 participants are identified. The inclusion criteria are:
Dialysing for greater than six months to ensure access patency, viability, and stability; Undergoing thrice weekly, four-hour dialysis sessions for uniform dialysis duration; Dialysing with an AVF, either brachio-cephalic or radio-cephalic; no central venous catheters, arteriovenous grafts, or femoral AVFs due to differences in access flows and vessel quality; BLOOD FLOW RATE 5 Dialysing with 15g needles as organization policy restricts greater flow rates with smaller needle gauge; Dialysing with a dialysate flow (Qd) of 500 mL/min to reduce the possibility of clearance being attributable to differences in Qd; Maintaining transonic vascular access flows of \>600 mL/min for the past 6 months, per KDOQI (NKF, 2006) minimum flow guidelines, to ensure access patency; Not part of any other research study that would interfere with dialysis treatment.
Data Collection Hourly documentation of Qb is routine protocol in the HD (hemodialysis) unit, along with Kt/V at each treatment termination. URR is routinely drawn every 6 weeks, however during this study it will be drawn weekly, on each third treatment. Standard URR blood draw protocol will be followed: a pre- and post- dialysis blood specimen will be collected and sent, along with the corresponding requisition, for analysis and calculation. A research account will be opened with LifeLabs (local laboratory service) and all research requisitions and blood will be coded and billed to the research study. Per unit protocol, blood draws will be written in the unit diary for nurse awareness, and blood collection tubes and requisition placed in participants' charts the night prior to treatment. Once weekly, the researchers will photocopy the participants' treatment run logs, along with the urea lab report, and data will be inputted into a CHEOS-approved excel spreadsheet. Along with Qb and Kt/V, collected data will include participants' blood pressure, dialysate flow rate, dialysis duration, needle gauge and cannulation, and occurrence of any intradialytic complications.
Data Analysis Data analysis will be conducted by CHEOS.
Sample
The target and sample population are end-stage renal disease patients dialysing with an arteriovenous fistula (AVF) at the Vancouver Community Dialysis Unit. Power analysis was conducted by the Centre for Health Evaluation and Outcome Sciences (CHEOS). To ensure a Kt/V of 1.3 and URR of 70% can be estimated with a confidence interval of 95%, a minimum sample size of 34 participants is required. An additional 10% is necessary to account for attrition. Because randomization will occur with study period assignment, purposive sampling will be used to select participants from the accessible pool (estimated at 60 patients), until 38 participants are identified. The inclusion criteria are:
Dialysing for greater than six months to ensure access patency, viability, and stability; Undergoing thrice weekly, four-hour dialysis sessions for uniform dialysis duration; Dialysing with an AVF, either brachio-cephalic or radio-cephalic; no central venous catheters, arteriovenous grafts, or femoral AVFs due to differences in access flows and vessel quality; BLOOD FLOW RATE 5 Dialysing with 15g needles as organization policy restricts greater flow rates with smaller needle gauge; Dialysing with a dialysate flow (Qd) of 500 mL/min to reduce the possibility of clearance being attributable to differences in Qd; Maintaining transonic vascular access flows of \>600 mL/min for the past 6 months, per KDOQI (NKF, 2006) minimum flow guidelines, to ensure access patency; Not part of any other research study that would interfere with dialysis treatment.
Data Collection Hourly documentation of Qb is routine protocol in the HD (hemodialysis) unit, along with Kt/V at each treatment termination. URR is routinely drawn every 6 weeks, however during this study it will be drawn weekly, on each third treatment. Standard URR blood draw protocol will be followed: a pre- and post- dialysis blood specimen will be collected and sent, along with the corresponding requisition, for analysis and calculation. A research account will be opened with LifeLabs (local laboratory service) and all research requisitions and blood will be coded and billed to the research study. Per unit protocol, blood draws will be written in the unit diary for nurse awareness, and blood collection tubes and requisition placed in participants' charts the night prior to treatment. Once weekly, the researchers will photocopy the participants' treatment run logs, along with the urea lab report, and data will be inputted into a CHEOS-approved excel spreadsheet. Along with Qb and Kt/V, collected data will include participants' blood pressure, dialysate flow rate, dialysis duration, needle gauge and cannulation, and occurrence of any intradialytic complications.
Data Analysis Data analysis will be conducted by CHEOS.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: