Ignite Creation Date:
2025-12-24 @ 2:54 PM
Ignite Modification Date:
2025-12-24 @ 2:54 PM
Study NCT ID:
NCT04052659
Status:
NOT_YET_RECRUITING
Last Update Posted:
2021-03-09
First Post:
2019-08-09
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Sintilimab (IBI308) in Combination With Chidamide and Azacitidine in Refractory or Relapsed PTCL
Sponsor:
Peking University
Organization:
Study Overview
Official Title:
A Study to Evaluate the Efficacy and Safety of Sintilimab (IBI308) in Combination With Chidamide and Azacitidine in the Refractory or Relapsed PTCL: A Phase 2, Single-center, Single-arm, Open Label Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a single-arm, single-center Phase II clinical trial for patients with relapsed or refractory Peripheral T-cell lymphoma (PTCL). Immunotherapy with anti-PD-1 antibodies, such as sintilimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chidamide and azacitidine may respectively stop the growth of tumor cells by blocking histone deacetylation and DNA methylation enzymes needed for cell growth. Giving chidamide and azacitidine with sintilimab these three drugs may work better than single drug or combination of two drugs in treating patients with relapsed or refractory peripheral T-cell lymphoma.
Detailed Description:
PRIMARY OBJECTIVES:
To determine the objective response rate (ORR).
SECONDARY OBJECTIVES:
1. To determine the complete response rate (CRR).
2. To determine the duration of response (DOR).
3. To determine the progression free survival (PFS).
4. To determine the overall survival (OS).
5. To determine the safety.
EXPLORATORY OBJECTIVES:
Assess the correlation between the expression of PD-L1, CD4, CD8, CD68 in tumor microenvironment and the efficacy of combined therapy in relapsed or refractory peripheral T-cell lymphoma.
To determine the objective response rate (ORR).
SECONDARY OBJECTIVES:
1. To determine the complete response rate (CRR).
2. To determine the duration of response (DOR).
3. To determine the progression free survival (PFS).
4. To determine the overall survival (OS).
5. To determine the safety.
EXPLORATORY OBJECTIVES:
Assess the correlation between the expression of PD-L1, CD4, CD8, CD68 in tumor microenvironment and the efficacy of combined therapy in relapsed or refractory peripheral T-cell lymphoma.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: