Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00137202
Status:
COMPLETED
Last Update Posted:
2008-07-28
First Post:
2005-08-25
Brief Title:
Post Burn Pruritus Study in Patients Undergoing Wound Healing
Sponsor:
United States Army Institute of Surgical Research
Organization:
United States Army Institute of Surgical Research
Study Overview
Official Title:
A Pilot Study to Determine the Pruritic Benefits of Ondansetron Versus Diphenhydramine in Burn Patients Undergoing Wound Healing
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to see if a drug called ondansetron Zofran controls itching from healing burn wounds as well or better than the usual drug used diphenhydramine Benadryl
Detailed Description:
A clear mechanism or cause for pruritus in patients recovering from burn has not been delineated
While the exact mechanismspathways for itching are currently unclear histamine antagonism appears to be the most popular treatment Whether histamine antagonism works predominantly via peripheral inhibition or central sedation is uncertain By treating another intermediary in the pruritus cascade it may be possible that an alternate treatment could be used while eliminating some of the unwanted side effects of antihistamine at the same time
While the exact mechanismspathways for itching are currently unclear histamine antagonism appears to be the most popular treatment Whether histamine antagonism works predominantly via peripheral inhibition or central sedation is uncertain By treating another intermediary in the pruritus cascade it may be possible that an alternate treatment could be used while eliminating some of the unwanted side effects of antihistamine at the same time
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None