Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00138944
Status:
COMPLETED
Last Update Posted:
2013-04-17
First Post:
2005-08-29
Brief Title:
Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension
Sponsor:
University of Erlangen-Nürnberg Medical School
Organization:
University of Erlangen-Nürnberg Medical School
Study Overview
Official Title:
Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension
Status:
COMPLETED
Status Verified Date:
2013-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Resistant hypertension is defined as hypertension not controlled ie blood pressure not below 14090 mmHg with the use of adequate doses of at least three different anti-hypertensives including a diuretic Resistant hypertension is abundant In the ALLHAT trial 34 of patients did not reach the blood pressure goal of 14090 mmHg One possible mechanism of resistance is the aldosterone-escape phenomenon
During aldosterone escape aldosterone plasma levels are normal or even elevated despite therapy with ACEIs or ARBs The prevalence is about 30-50 Possible reasons for aldosterone escape are alternative ways of aldosterone stimulation hyperkalemia adrenomedullin ACTH local aldosterone production or primary aldosteronism Aldosterone has deleterious blood pressure independent effects on cardiac vascular and renal damage
Hypothesis Eplerenone is effective to improve hypertensive target organ damage in patients with resistant hypertension
During aldosterone escape aldosterone plasma levels are normal or even elevated despite therapy with ACEIs or ARBs The prevalence is about 30-50 Possible reasons for aldosterone escape are alternative ways of aldosterone stimulation hyperkalemia adrenomedullin ACTH local aldosterone production or primary aldosteronism Aldosterone has deleterious blood pressure independent effects on cardiac vascular and renal damage
Hypothesis Eplerenone is effective to improve hypertensive target organ damage in patients with resistant hypertension
Detailed Description:
see above
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DFG KFO 106-2 TP5 | None | None | None |