Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00142844
Status:
COMPLETED
Last Update Posted:
2017-01-12
First Post:
2005-09-01
Brief Title:
Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
Sponsor:
University of Pennsylvania
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
Two Medications Disulfiram and Naltrexone in the Treatment of Patients With Both Cocaine and Alcohol Dependence
Status:
COMPLETED
Status Verified Date:
2016-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Many cocaine dependent individuals are also dependent on alcohol Such individuals respond poorly to existing treatments and have received little research attention in the past The purpose of this study is to determine whether the combination of naltrexone and disulfiram is useful in decreasing alcohol use and cravings in people diagnosed with both cocaine and alcohol dependence
Detailed Description:
Many cocaine dependent individuals are also dependent on alcohol Such individuals respond poorly to existing treatments and have received little research attention in the past Naltrexone and disulfiram are medications currently approved for treating alcohol dependence These two medications have different mechanisms of action in the body In combination they might be effective in treating individuals dually diagnosed with cocaine and alcohol dependence The purpose of this study is to determine whether the combination of naltrexone and disulfiram is useful in decreasing alcohol cravings in individuals who are dependent on both cocaine and alcohol
Participants in this 5-year double-blind study will be randomly assigned to receive disulfiram naltrexone both or placebo Treatment will occur for a 3-month period after which alcohol cocaine use and other biopsychosocial measures will be assessed at Months 6 and 9
Participants in this 5-year double-blind study will be randomly assigned to receive disulfiram naltrexone both or placebo Treatment will occur for a 3-month period after which alcohol cocaine use and other biopsychosocial measures will be assessed at Months 6 and 9
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DPMC | OTHER | NIDA | httpsreporternihgovquickSearchP50DA012756-01 |
| P50DA012756-01 | NIH | None | None |