Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001876
Status:
COMPLETED
Last Update Posted:
2022-09-29
First Post:
1999-11-03
Brief Title:
Lung Disease Associated With Rheumatoid Arthritis
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Pulmonary Fibrosis Associated With Rheumatoid Arthritis Definition of the Natural History of Disease
Status:
COMPLETED
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pulmonary fibrosis PF is a condition in which the lungs of a patient become scarred and fibrous It has been known to occur in as many as 40 of patients diagnosed with rheumatoid arthritis RA The cause of the pulmonary fibrosis in patients with RA is unknown
Patients participating in this study will undergo a series of tests and examinations before and throughout the study The tests include blood and urine tests electrical measures of heart function ECG chest x-rays CAT scans nuclear medicine scans breathing tests exercise tests and fiberoptic bronchoscopy
The goals of this study are to
1 Estimate how common pulmonary fibrosis is in patients with rheumatoid arthritis
2 Describe the natural course of pulmonary fibrosis in patients with rheumatoid arthritis
3 Estimate the survival rate of patients with pulmonary fibrosis and rheumatoid arthritis and
4 Learn more about the factors that contribute to the development or progression fibrotic lung disease
Patients participating in this study will undergo a series of tests and examinations before and throughout the study The tests include blood and urine tests electrical measures of heart function ECG chest x-rays CAT scans nuclear medicine scans breathing tests exercise tests and fiberoptic bronchoscopy
The goals of this study are to
1 Estimate how common pulmonary fibrosis is in patients with rheumatoid arthritis
2 Describe the natural course of pulmonary fibrosis in patients with rheumatoid arthritis
3 Estimate the survival rate of patients with pulmonary fibrosis and rheumatoid arthritis and
4 Learn more about the factors that contribute to the development or progression fibrotic lung disease
Detailed Description:
Pulmonary fibrosis is an extra-articular manifestation of rheumatoid arthritis whose etiology remains uncertain Although the clinical course of many individuals with this disorder can mimic that observed in patients with idiopathic pulmonary fibrosis the natural history of fibrotic lung disease associated with rheumatoid arthritis remains largely undefined It is the intent of this clinical protocol to 1 estimate the prevalence of pulmonary fibrosis in individuals with rheumatoid arthritis 2 define the natural history of pulmonary fibrosis in patients with rheumatoid arthritis 3 estimate the survival rate of individuals with pulmonary fibrosis and rheumatoid arthritis and 4 examine pulmonary physiologic radiologic and biochemical markers that predict the development or progression of fibrotic lung disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-HG-0056 | None | None | None |