Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00142727
Status:
TERMINATED
Last Update Posted:
2017-01-12
First Post:
2005-09-01
Brief Title:
Opioid Agonist and Antagonist Effects on Opioid Dependence
Sponsor:
National Institute on Drug Abuse NIDA
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
The Variability of Agonist and Antagonist Effects as a Function of Level of Physical Dependence
Status:
TERMINATED
Status Verified Date:
2007-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Study terminated due to halt in funding may resume recruiting in future
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication an opioid antagonist medication and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence
Detailed Description:
The pharmacological effects of opioids in opioid dependent individuals can vary as a function of the characteristics of the opioid being studied eg whether it is an agonist partial agonist or antagonist the dose administered and the route of administration Another important set of factors influencing the effects produced by opioids is the characteristics of the organism to which the opioid is being administered One such characteristic is the level of physical dependence in individuals
Participants in this study will be maintained on different dose levels of an opioid agonist methadone The participant will be challenged with a prototypic opioid agonist antagonist and a mixed agonist-antagonist with partial agonist features in order to determine the effects that each has on the human body
Participants in this study will be maintained on different dose levels of an opioid agonist methadone The participant will be challenged with a prototypic opioid agonist antagonist and a mixed agonist-antagonist with partial agonist features in order to determine the effects that each has on the human body
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DPMC | None | None | None |
| R01-08045-6 | None | None | None |