Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001925
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Effect of Alcohol on Tremors
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Effect of Alcohol on Physiologic and Pathologic Tremors
Status:
COMPLETED
Status Verified Date:
2002-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tremors are involuntary movements of a part or parts of the body that occur because of alternating contraction and relaxation of muscles The causes behind most tremors are poorly understood
Some studies suggest tremors could be caused by abnormalities in a particular area of the brain called the olivary nucleus Researchers believe that the cells making up the olivary nucleus may be responsible for generating a central rhythm of the body and may therefore also be responsible for the generation of tremors
Consumption of alcohol has been known to reduce tremors in some patients Researchers believe that the alcohol may work directly on the cells of the olivary nucleus As a result researchers would like to determine the effects of alcohol on three different kinds of tremors physiological symptomatic palatal and essential palatal
Some studies suggest tremors could be caused by abnormalities in a particular area of the brain called the olivary nucleus Researchers believe that the cells making up the olivary nucleus may be responsible for generating a central rhythm of the body and may therefore also be responsible for the generation of tremors
Consumption of alcohol has been known to reduce tremors in some patients Researchers believe that the alcohol may work directly on the cells of the olivary nucleus As a result researchers would like to determine the effects of alcohol on three different kinds of tremors physiological symptomatic palatal and essential palatal
Detailed Description:
The pathophysiology and anatomical basis of most tremors remains poorly understood One particular theory of essential tremor the olivary hypothesis has gained support from various studies These studies point to the olivary nucleus as possible central rhythm generator Cells in the olivary nucleus show spontaneous rhythmic discharges that can be suppressed by alcohol Since alcohol is known to suppress tremor in some patients with essential tremor one can theorize that it is through its effect on the olivary nucleus that is the inferior olive is the generator of the tremor Given this assumption we intend to study the effect of alcohol on three different kinds of tremor the 8-12 Hz component of physiological tremor symptomatic palatal tremor and essential palatal tremor Our hypothesis is that the central generator of each of these types of tremor lies in the inferior olive and that the ingestion of alcohol should reduce the amplitude of the tremor similar to the effect of alcohol seen in essential tremor
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-N-0030 | None | None | None |