Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00141778
Status:
COMPLETED
Last Update Posted:
2013-03-22
First Post:
2005-08-30
Brief Title:
Renin-angiotensin-aldosterone System RAAS Inflammation and Post-Operative Atrial Fibrillation AF
Sponsor:
Vanderbilt University
Organization:
Vanderbilt University
Study Overview
Official Title:
RAAS Inflammation and Post-operative AF
Status:
COMPLETED
Status Verified Date:
2013-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Atrial fibrillation AF is the most prevalent sustained type of irregular heartbeat and affects over 2 million Americans Post-operative AF which leads to significant morbidity and a prolonged hospital stay complicates 20 to 40 of cardiopulmonary bypass CPB surgical procedures While recent studies indicate that interruption of the renin-angiotensin-aldosterone system by either angiotensin-converting enzyme ACE inhibition or AT1 receptor antagonism decreases the incidence of AF following a heart attack or cardioversion electric shock to the heart its effect on the incidence of post-operative AF has not been throughly studied Studies in both animals and humans suggest that inflammation-induced atrial remodeling plays an important role in the cause of AF Recent studies also provide evidence that activation of the renin-angiotensin-aldosterone system induces inflammation myocyte injury proarrhythmic electrical remodeling and fibrosis through aldosterone
Detailed Description:
AF is the most prevalent sustained type of irregular heartbeat and affects over 2 million Americans Post-operative atrial fibrillationAF which leads to significant morbidity and a prolonged hospital stay complicates 20 to 40 of CPB surgical procedures While recent studies indicate that interruption of the renin-angiotensin-aldosterone system by either angiotensin-converting enzymeACE inhibition or angiotensin II subtype 1 AT1 receptor antagonism decreases the incidence of AF following a heart attack or cardioversion electric shock to the heart its effect on the incidence of post-operative AF has not been throughly studied Studies in both animals and humans suggest that inflammation-induced atrial remodeling plays an important role in the cause of AF Recent studies also provide evidence that activation of the renin-angiotensin-aldosterone system induces inflammation myocyte injury proarrhythmic electrical remodeling and fibrosis through aldosterone
This study will evaluate the effectiveness of ACE inhibition and aldosterone receptor antagonism at decreasing inflammation and AF following cardiopulmonary bypass CPB surgery
This study will evaluate the effectiveness of ACE inhibition and aldosterone receptor antagonism at decreasing inflammation and AF following cardiopulmonary bypass CPB surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL077389 | NIH | None | httpsreporternihgovquickSearchR01HL077389 |