Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005435
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Hostility and Pathogenic Mechanisms of Coronary Heart Disease in Women
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the combined effects of hostility harassment lipids and oral contraceptive 0C use on physiological responses in young and middle-aged premenopausal women
Detailed Description:
BACKGROUND
Preliminary findings already have shown that in contrast to women with low scores on the Cook and Medley Hostility Ho scale women with high Ho scores exhibit greater cardiovascular changes to harassment Additional findings have suggested that oral contraceptive 0C use may also be associated with increased behaviorally-induced physiological changes especially in low Ho women Similarly higher levels of total serum cholesterol TSC have been positively associated with greater stress-induced neurohormonal changes in middle-aged men with high Ho scores
DESIGN NARRATIVE
Assessment of autonomic activity took place in the laboratory and during a 24 hour ambulatory measurement period Hostility was measured with the Cook and Medley Hostility scale The laboratory assessment helped to determine if high hostility women responded to harassment with greater cardiovascular and neurohormonal changes than low hostility women and if this relationship was altered by 0C use lipids and age The ambulatory assessment of autonomic activity allowed an exploration of the responses of high and low hostility subjects to daily-life stressors Several hypothesis were explored 1 Did harassment produce neuroendocrine as well as cardiovascular hyperreactivity in young women and did this hyperreactivity generalize from laboratory to real-life 2 Were the harassment-induced cardiovascular and neuroendocrine changes in young women also present in middle-aged women 3 To what extent did 0C use modulate the cardiovascular and neuroendocrine responses to harassment in young women and was 0C use also altering the hostility--related associations between lipids and reactivity 4 Were the differential lipid-reactivity associations observed in middle-aged men as a function of high and low hostility scores present in women and if so were they modulated by age
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Preliminary findings already have shown that in contrast to women with low scores on the Cook and Medley Hostility Ho scale women with high Ho scores exhibit greater cardiovascular changes to harassment Additional findings have suggested that oral contraceptive 0C use may also be associated with increased behaviorally-induced physiological changes especially in low Ho women Similarly higher levels of total serum cholesterol TSC have been positively associated with greater stress-induced neurohormonal changes in middle-aged men with high Ho scores
DESIGN NARRATIVE
Assessment of autonomic activity took place in the laboratory and during a 24 hour ambulatory measurement period Hostility was measured with the Cook and Medley Hostility scale The laboratory assessment helped to determine if high hostility women responded to harassment with greater cardiovascular and neurohormonal changes than low hostility women and if this relationship was altered by 0C use lipids and age The ambulatory assessment of autonomic activity allowed an exploration of the responses of high and low hostility subjects to daily-life stressors Several hypothesis were explored 1 Did harassment produce neuroendocrine as well as cardiovascular hyperreactivity in young women and did this hyperreactivity generalize from laboratory to real-life 2 Were the harassment-induced cardiovascular and neuroendocrine changes in young women also present in middle-aged women 3 To what extent did 0C use modulate the cardiovascular and neuroendocrine responses to harassment in young women and was 0C use also altering the hostility--related associations between lipids and reactivity 4 Were the differential lipid-reactivity associations observed in middle-aged men as a function of high and low hostility scores present in women and if so were they modulated by age
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R29HL046283 | NIH | None | httpsreporternihgovquickSearchR29HL046283 |