Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004361
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone iPTH in Adults With Repaired or Palliated Conotruncal Cardiac Defects
Sponsor:
National Center for Research Resources NCRR
Organization:
Office of Rare Diseases ORD
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Identify latent hypoparathyroidism in normocalcemic adult survivors with repaired conotruncal cardiac defects by evaluating parathyroid gland secretory function after induced hypocalcemia
II Determine the relationship of parathyroid hormone secretion to microdeletions in the same region of chromosome 22q11 as found in patients with DiGeorge anomaly
II Determine the relationship of parathyroid hormone secretion to microdeletions in the same region of chromosome 22q11 as found in patients with DiGeorge anomaly
Detailed Description:
PROTOCOL OUTLINE
Patients are given sodium citrate over a 2 hour infusion on day 1 Blood is drawn at times -30 -15 0 and every 10 minutes thereafter during the infusion On day 2 patients are given calcium gluconate over a 2 hour infusion Blood is drawn at times -30 -15 0 and every 10 minutes thereafter during the infusion
Patients are given sodium citrate over a 2 hour infusion on day 1 Blood is drawn at times -30 -15 0 and every 10 minutes thereafter during the infusion On day 2 patients are given calcium gluconate over a 2 hour infusion Blood is drawn at times -30 -15 0 and every 10 minutes thereafter during the infusion
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NU-553 | None | None | None |