Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00140231
Status:
COMPLETED
Last Update Posted:
2017-06-07
First Post:
2005-08-30
Brief Title:
Role of Leptin in the Neuroendocrine and Immune Response to Fasting
Sponsor:
Beth Israel Deaconess Medical Center
Organization:
Beth Israel Deaconess Medical Center
Study Overview
Official Title:
Role of Leptin in the Neuroendocrine and Immune Response to Fasting in Humans
Status:
COMPLETED
Status Verified Date:
2017-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study will be to determine whether giving leptin r-metHuLeptin to a person when he or she is fasting will reverse changes in metabolism and hormone levels and immune function associated with fasting which decreases leptin levels
Detailed Description:
Leptin is a hormone secreted by fat cells under normal conditions and acts in the brain to decrease appetite and increase energy use Leptin levels usually go down with fasting This study will evaluate the secretion of an investigational agent called leptin in lean and overweight individuals while fasting and investigate the potential role of leptin as a regulator of immune function and mediator of the neuroendocrine response to food deprivation in humans Data derived from these studies will provide insights into the mechanisms underlying altered hormone levels and immune function in malnutrition and obesity and thus may provide the basis for future therapeutic interventions for obesity
Comparison fed state vs fasting state vs fasting leptin state
Comparison fed state vs fasting state vs fasting leptin state
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2M01RR001032-30 | NIH | None | None |
| 5R01DK058785-07 | NIH | None | httpsreporternihgovquickSearch5R01DK058785-07 |