Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00141973
Status:
COMPLETED
Last Update Posted:
2008-05-14
First Post:
2005-09-01
Brief Title:
Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids
Sponsor:
Ospedale Regionale Bellinzona e Valli
Organization:
Ospedale Regionale Bellinzona e Valli
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases Since the production of CRP is down-regulated by corticosteroids a smaller increase or a more rapid decrease of this acute phase protein will
1 suggest attenuated systemic inflammation but
2 does not necessarily reflect adequate therapy of the infection
For several reasons good diagnostic tool for sepsis induction not decreased by immunosuppressive therapy procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment
1 suggest attenuated systemic inflammation but
2 does not necessarily reflect adequate therapy of the infection
For several reasons good diagnostic tool for sepsis induction not decreased by immunosuppressive therapy procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None