Ignite Creation Date:
2024-05-06 @ 2:20 AM
Last Modification Date:
2024-10-26 @ 11:17 AM
Study NCT ID:
NCT02026973
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2013-12-31
Brief Title:
Impact of Endogenous E2 on SSI and GH Rebound
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Impact of Endogenous Estrogen on Somatostatin Inhibition and Growth Hormone Rebound in Older Women
Status:
COMPLETED
Status Verified Date:
2016-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Endogenous estrogens maintain growth hormone GH secretion in postmenopausal women by potentiating endogenous GH-releasing hormone GHRH drive and restraining somatostatin inhibition of GH release
Detailed Description:
Systemic concentrations of testosterone Te estradiol E2 GH IGF-I and IGFBP-3 decline in healthy aging individuals 1-3 Sex-steroid deprivation accentuates GH and IGF-I depletion since Te and E2 stimulate GH and IGF-I production in older adults hypogonadal patients of all ages and patients undergoing gender reassignment 124 Tamoxifen blocks the effect of Te suggesting involvement of E2 in GHs stimulation in men 5 E2 also stimulates GH secretion in women putatively via the nuclear estrogen receptor ER-alpha 1267 Because Te E2 and GH fall with menopause and Te is converted to E2 by aromatization in the body 8-10 we postulate that diminished Te concentrations TeE2 concentrations and low E2 mediate low GH output in older women What remains unknown is whether the low E2 levels in postmenopausal women retain GH-stimulating effects To test this notion would require blocking i aromatase-enzyme activity which mediates E2 synthesis from Te andor ii estrogen receptor-alpha which transduces most of E2s stimulation of the GH axis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None