Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00159068
Status:
COMPLETED
Last Update Posted:
2017-08-10
First Post:
2005-09-09
Brief Title:
Analysis of Genetic Factors Which May Influence the Course of HIV Infection
Sponsor:
Deborah Rund
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
Genetic Influences on the Course and Response to Treatment of HIV Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms
Status:
COMPLETED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with HIV an have a variable course of their infection We are trying to identify factors which worsen or ameliorate the course of the disease Such factors may be related to metabolism breakdown of drugs or to iron handling by the body
Detailed Description:
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4 In addition reports have linked changes in the course of the disease with iron status with high iron being detrimental We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters such as CD4 counts and opportunistic infections
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None