Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00158028
Status:
COMPLETED
Last Update Posted:
2016-08-04
First Post:
2005-09-08
Brief Title:
Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder
Sponsor:
Icahn School of Medicine at Mount Sinai
Organization:
Icahn School of Medicine at Mount Sinai
Study Overview
Official Title:
Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder
Status:
COMPLETED
Status Verified Date:
2016-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the efficacy of risperidone compared to placebo in the treatment of the psychotic-like and deficit symptoms of schizotypal personality disorder SPD Treatment with risperidone a 5HT2 and dopamine D2 blocking agent holds particular promise in the treatment of SPD Unlike traditional antipsychotics risperidone targets the deficit or negative symptoms of schizophrenia The deficit-like symptoms of SPD are therefore also likely respond to treatment with risperidone One common complication in the present psychopharmacologic treatment of SPD with traditional neuroleptics is the fact that many patients discontinue treatment due to the medication-induced dysphoria Given initial reports and the serotonergic component of the risperidone mechanism risperidone is anticipated to produce little or no dysphoria
Detailed Description:
All patients receive a comprehensive medical evaluation prior to their participation in any studies as part of their normal clinical care The evaluation includes an extensive medical history physical examination and laboratory evaluation including SMA-18 CBC with differential TFTs UA stool guaiac serology drug screen chest X-ray where indicated EKG and for women pregnancy test Note Subjects will have consented to these procedures in a separate consent Biological Correlates of Personality Disorder- Information for Subjects 88244 before being invited to join this study Patients will be interviewed by clinical psychology doctoral students trained in the use of structured instruments to assess Axis I and Axis II pathology A rater will independently complete either the Schedule for Affective Disorders and Schizophrenia SADS Spitzer Endicott 1978 modified for evaluation of DSM-IV criteria for Axis 1 disorders or the Structured Clinical Interview for DSM-IV Axis I Disorders First et al 1996 and the Structured Interview for DSM-III-R Personality Disorders SIDP-R Pfohl et al 1989 also modified for the evaluation of DSM-IV criteria When possible information will be gathered independently from an informant first degree relative or life-long friend to supplement information obtained from clinical interviews and review of past records The use of structured interviews and questionnaires are not part of standard clinical care
PART 1 Part 1 is a single-blind two-week placebo washout Patients will be seen weekly by a research psychiatrist One week of placebo medication will be dispensed at a time by a research program physician under the direct supervision of Dr Koenigsberg Patients will be seen weekly throughout the study Interviews and assessments are standardized and identical throughout all phases of the study They include the Clinical Global Impression scale CGI the Scale for the Assessment of Negative Symptoms SANS the Positive and Negative Symptom Scale PANSS and the Hamilton Depression Rating Scale HDRS all administered weekly At baseline and after 4- and 9-weeks of treatment subjects will also receive a series of paper-and-pencil and computer-presented cognitive tests DOT test Paced Auditory Serial Addition Task Continuous Performance Task-Identical Pairs version Serial Verbal Learning Test and the Wechsler memory Scale-Revised Visual Reproduction test No medications other than study drug are allowed during the protocol If during this two-week placebo washout period the total SANS score decreases by 35 or greater patients will not be entered into Phase 2 Use of a placebo washout is not part of standard clinical care
PART 2 Part 2 is the double blind 9-week parallel-arm placebo-controlled portion of the study Randomization will be conducted by the Pharmacy One week of medication active or placebo will be dispensed at a time by a research program physician under the direct supervision of Dr Koenigsberg The patient will receive 1 tablet PO QD every day of the study If enrolled in the Active Arm of the study the patient will receive a 25 mg risperidone tablet orally once daily for Days 1 to 7 5 mg risperidone tablet orally once daily for Days 8 to 21 1 mg risperidone tablet orally once daily for Days 22-35 15 mg risperidone tablet orally once daily for days 36-49 and a 2 mgs of risperidone orally once daily for days 50 to 63 If the treating psychiatrist believes that a higher dose is clinically indicated the physician may alter the above by increasing the dose to 2 mg per day beginning on day 22 and to 4 mg per day beginning on day 50 Weekly visits will include standard assessment and review of protocol compliance Treatment with risperidone is not part of current standard clinical care of schizotypal personality disorder and this study is designed to establish its usefulness with this population Similarly use of a double bind placebo control is not part of standard clinical care
PART 3 Patients who were randomized into the placebo arm of Part 2 will be offered the opportunity of participating in an 8 week open label study of risperidone otherwise identical to Part 2
Data will be analyzed by a repeated measures analysis of variance separately for scores on the CGI SANS PANSS and HDSR comparing placebo and active medication
PART 1 Part 1 is a single-blind two-week placebo washout Patients will be seen weekly by a research psychiatrist One week of placebo medication will be dispensed at a time by a research program physician under the direct supervision of Dr Koenigsberg Patients will be seen weekly throughout the study Interviews and assessments are standardized and identical throughout all phases of the study They include the Clinical Global Impression scale CGI the Scale for the Assessment of Negative Symptoms SANS the Positive and Negative Symptom Scale PANSS and the Hamilton Depression Rating Scale HDRS all administered weekly At baseline and after 4- and 9-weeks of treatment subjects will also receive a series of paper-and-pencil and computer-presented cognitive tests DOT test Paced Auditory Serial Addition Task Continuous Performance Task-Identical Pairs version Serial Verbal Learning Test and the Wechsler memory Scale-Revised Visual Reproduction test No medications other than study drug are allowed during the protocol If during this two-week placebo washout period the total SANS score decreases by 35 or greater patients will not be entered into Phase 2 Use of a placebo washout is not part of standard clinical care
PART 2 Part 2 is the double blind 9-week parallel-arm placebo-controlled portion of the study Randomization will be conducted by the Pharmacy One week of medication active or placebo will be dispensed at a time by a research program physician under the direct supervision of Dr Koenigsberg The patient will receive 1 tablet PO QD every day of the study If enrolled in the Active Arm of the study the patient will receive a 25 mg risperidone tablet orally once daily for Days 1 to 7 5 mg risperidone tablet orally once daily for Days 8 to 21 1 mg risperidone tablet orally once daily for Days 22-35 15 mg risperidone tablet orally once daily for days 36-49 and a 2 mgs of risperidone orally once daily for days 50 to 63 If the treating psychiatrist believes that a higher dose is clinically indicated the physician may alter the above by increasing the dose to 2 mg per day beginning on day 22 and to 4 mg per day beginning on day 50 Weekly visits will include standard assessment and review of protocol compliance Treatment with risperidone is not part of current standard clinical care of schizotypal personality disorder and this study is designed to establish its usefulness with this population Similarly use of a double bind placebo control is not part of standard clinical care
PART 3 Patients who were randomized into the placebo arm of Part 2 will be offered the opportunity of participating in an 8 week open label study of risperidone otherwise identical to Part 2
Data will be analyzed by a repeated measures analysis of variance separately for scores on the CGI SANS PANSS and HDSR comparing placebo and active medication
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None