Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00154661
Status:
COMPLETED
Last Update Posted:
2005-09-12
First Post:
2005-09-08
Brief Title:
Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis
Status:
COMPLETED
Status Verified Date:
2001-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
we hypothesize that PTX might be effective in lowering proteinuria by modulating renal MCP-1 production in human glomerulonephritis
Detailed Description:
Pentoxifylline PTX is a phosphodiesterase inhibitor that is widely used for the treatment of peripheral vascular occlusive disorders In addition PTX has shown its ability to attenuate nephrotic syndrome secondary to membranous glomerulonephritis and lupus nephritis and to reduce subnephrotic proteinuria due to early and advanced diabetic nephropathy However data with respect to its effect on non-nephrotic primary glomerular diseases are lacking Moreover while the anti-proteinuric effect of PTX has been largely attributed to down-regulation of TNF-a it remains unknown whether other mediators especially MCP-1 are also affected by PTX Because our previous works have shown that PTX attenuates proteinuria and suppresses renal MCP-1 mRNA expression in experimental glomerulonephritis in rats we hypothesize that PTX might be effective in lowering proteinuria by modulating renal MCP-1 production in human glomerulonephritis This study was thereby conducted to investigate the potential anti-proteinuric and anti-MCP-1 effects of PTX in subnephrotic patients with primary glomerular diseases
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None