Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00154037
Status:
COMPLETED
Last Update Posted:
2006-09-13
First Post:
2005-09-08
Brief Title:
Investigation of Vascular Relaxing Effects of Candesartan and Pioglitazone
Sponsor:
Technische Universität Dresden
Organization:
Technische Universität Dresden
Study Overview
Official Title:
Characterization of Vascular Effects of Candesartan and Pioglitazone
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study is designed to test the hypothesis in healthy subjects that candesartan and pioglitazone provide additional vascular relaxing or modulating effects in addition to their blood-pressure and blood glucose level reducing ability respectively
Detailed Description:
The aim of the study is to investigate the effect of oral candesartan and or rosiglitazone therapy on the vascular responsiveness of different vasoactive compounds angiotensin II insulin histamine and glyceroltrinitrate in healthy subjects Pioglitazone will be given orally 4 weeks 30mgd titrated to 45 mgd for another 4 weeks Candesartan will be given orally 4 weeks 8mgd titrated to 16 mgd for another 4 weeks as treatment Every subject will receive intravenous stimulation with phenylephrine angiotensin II histamine insulin and glyceroltrinitrate before and after an 8 weeks treatment interval with study medication or placebo In addition pulse wave velocity will me measured non-invasively before and after treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None