Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00155519
Status:
COMPLETED
Last Update Posted:
2005-11-28
First Post:
2005-09-09
Brief Title:
A Psychopathological Study of Latent Early Schizophrenia Clinical PathologyNeuropsychological Dysfunctions
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
A Psychopathological Study of Latent Early Schizophrenia Clinical PathologyNeuropsychological Dysfunctions
Status:
COMPLETED
Status Verified Date:
2000-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Current diagnostic criteria of schizophrenia are based on marked positive and negative symptoms This definition may impede the exploration of basic phenomenological psychopathology or pathological mechanism of schizophrenia Schizophrenia was found to have neuroanatomical neurophysiological and neuropsychological impairment However the existence of these basic pathological states may not manifest as clinical state of schizophrenia and it is found in normal relatives of schizophrenia proband The clinical state of this underlying pathology may include so-called latent or early or pseudo-neurotic schizophrenia or schizotypal disorder The manifestation of prominent neurotic symptom state may not only present as an psychopathological issue but also induce misdiagnosis in clinical practice This may interfere early diagnosis of schizophrenia and may delay the chance of early and appropriate treatment
Taking the fact of this disadvantaged conditions this research is for exploration of clinical pathology and neuropsychological functions of latent or pseudo-neurotic schizophrenia The strategy ia a natural follow-up study on the clinical cases obtained from the registration record of the medical charts of the National Taiwan University Hospital from 1970 to 1995 The natural follow-up results till study time 5 yrs to 30 yrs following period will be explored By using neurotic group 50 cases latent schizophrenia group 50 cases and schizotypal group 30 cases the differences in clinical pathology neuropsychological functions and family history of schizophrenia will be examined There are 5 hypotheses to be tested 1 Schizotaxia may exist as the manifestations of latent schizophrenia schizotypal disorder and frank schizophrenia The severity of pathology increased step by step 2 The syndrome may change from the lower order to higher order to higher order but not all of them changed to the higher order 3 The clinical pathology of latent schizophrenia has both neurotic symptom as well as basic symptoms of schizophrenia 4 There is the same kind of neuropsychological impairment of schizophrenia in the group of latent schizophrenia and 5 The prevalence of schizophrenia in the first degree relatives of latent schizophrenia is higher than that of the general population Finally this study results will help the establishment of valid screening andor diagnostic method criteria of latent schizophrenia for clinical and research usage
Taking the fact of this disadvantaged conditions this research is for exploration of clinical pathology and neuropsychological functions of latent or pseudo-neurotic schizophrenia The strategy ia a natural follow-up study on the clinical cases obtained from the registration record of the medical charts of the National Taiwan University Hospital from 1970 to 1995 The natural follow-up results till study time 5 yrs to 30 yrs following period will be explored By using neurotic group 50 cases latent schizophrenia group 50 cases and schizotypal group 30 cases the differences in clinical pathology neuropsychological functions and family history of schizophrenia will be examined There are 5 hypotheses to be tested 1 Schizotaxia may exist as the manifestations of latent schizophrenia schizotypal disorder and frank schizophrenia The severity of pathology increased step by step 2 The syndrome may change from the lower order to higher order to higher order but not all of them changed to the higher order 3 The clinical pathology of latent schizophrenia has both neurotic symptom as well as basic symptoms of schizophrenia 4 There is the same kind of neuropsychological impairment of schizophrenia in the group of latent schizophrenia and 5 The prevalence of schizophrenia in the first degree relatives of latent schizophrenia is higher than that of the general population Finally this study results will help the establishment of valid screening andor diagnostic method criteria of latent schizophrenia for clinical and research usage
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC-90-2413-H-0052-023 | None | None | None |
| NSC-89-2413-H-002-042 | None | None | None |