Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00155194
Status:
UNKNOWN
Last Update Posted:
2005-09-12
First Post:
2005-09-09
Brief Title:
Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Null hypothesis of this study Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect
Detailed Description:
Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model Systemic humoral immunity total serum IgG IgA IgM C3 and C4 specific cellular immunity lymphocyte classification mitogen response cytokines level after PHA stimulation test and non-specific cellular immunity absolute neutrophil count PMN CD11bCD18 expression level PMN superoxide release function and PMN phagocytosis function were tested Association with serum bilirubin level nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None