Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00155116
Status:
UNKNOWN
Last Update Posted:
2005-11-23
First Post:
2005-09-09
Brief Title:
SERPIN D1 and Its Role in Lung Cancer Invasion and Metastasis
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2004-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the correlation between SERPIN D1 expression in clinical specimen including surgical specimen and blood sample and lung cancer metastasis
Detailed Description:
Lung cancer is the leading cause of cancer death in Taiwan and world wild Although there were progresses in the diagnosis and treatment of lung cancer the incidence and mortality rate of lung cancer increased in recent years In many cases lung cancer is not diagnosed and treated until cancer cells have already invaded surrounding tissues and metastasized throughout the body Only 15 of lung cancer patients were operable at presentation and about half of them had long term survival The remaining almost died of metastatic disease Detecting lung cancers when they are at their earliest stages and identify cancers with metastatic potential will have a higher probability of truly curing the disease Molecules that are expressed uniquely or at high level by tumor cells in comparison to normal tissues and that may be secreted into accessible fluids such as blood urine or sputum may be useful as lung cancer biomarkers By using tools in SAGE Genie of Cancer Genome Anatomy Project CGAP we identified a secreted protein SERPIN D1 as an overexpressed gene in non-small cell lung cancer as compared with normal lung and any other normal tissue In an established panel of human lung adenocarcinoma cell lines with different invasive activities CL1-0 cells and its sublines CL1-1 and CL1-5 in ascending order of activity we detected that the expression of SERPIN D1 was higher in CL1-5 than in CL1-0 and CL1-1 According to our preliminary results we hypothesize that SERPIN D1 may play a role in lung cancer invasion and metastasis and may serve as a serum biomarker for prognosis stratification For this study we are going to evaluate the potential correlation between SERPIN D1 expression in clinical specimen including surgical specimen and blood sample and lung cancer metastasis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None