Ignite Creation Date:
2024-05-06 @ 2:41 AM
Last Modification Date:
2024-10-26 @ 11:22 AM
Study NCT ID:
NCT02103920
Status:
UNKNOWN
Last Update Posted:
2014-04-04
First Post:
2012-04-02
Brief Title:
A Retrospective Immunohistochemistry Study of the Expression of Glycine Serine Pathway Molecules in Solid Tumors
Sponsor:
National University Hospital Singapore
Organization:
National University Hospital Singapore
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2014-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the expression of molecules involved in the glycineserine pathway using immunohistochemistry in solid tumors Archived paraffin-embedded pathological specimens from the Department of Pathology NUH will be obtained Tissue microarray TMA is a high-throughput method of analysing large numbers of formalin-fixed paraffin-embedded tumor at a minimal cost and effort To analyse the expression of molecules of putative relevance to the glycineserine pathway such as PSPH PSAT1 SHMT1 and GLDC TMA technology will be utilised as previously reported Kristiansen Zhang Soong Tissue arrays will be constructed from solid tumors including cancers of the colon rectum lung breast cervix ovary endometrium fallopian tube prostate kidney testis stomach liver brain and lymphoma One hundred cases of each tumor type subject to availability will be stained using immunohistochemistry Patient Identifiers will not be collected Societal benefit in terms of knowledge gained to improve understanding of cancer No direct risk to subjects as this is a retrospective study of archived pathological tumour samples
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None