Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00160745
Status:
COMPLETED
Last Update Posted:
2018-02-26
First Post:
2005-09-06
Brief Title:
Rosuvastatin and Renal Endothelial Function
Sponsor:
University of Erlangen-Nürnberg Medical School
Organization:
University of Erlangen-Nürnberg Medical School
Study Overview
Official Title:
A Randomised Double-blind Placebo-controlled Mono-centre Explorative Phase II Trial to Study the Effects of Rosuvastatin on Basal Production and Release of Nitric Oxide From the Renal Vasculature in Patients With Hypercholesterolemia
Status:
COMPLETED
Status Verified Date:
2018-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The endothelium plays an important role in the regulation of vascular tone and regulation of blood flow Nitric oxide NO is the most important known endothelium-derived vasodilating factor Prospective studies have shown that hypercholesterolemia impairs endothelial function in different vascular beds Lowering total cholesterol and particularly LDL-cholesterol with statins leads to an improvement in endothelium-dependent vasodilation in the forearm vasculature There is strong evidence to suggest that the benefit is not merely related to the decrease in cholesterol-levels A recent study in the forearm vasculature demonstrated that short-term lipid-lowering therapy improves endothelial function and NO availability already after 3 days of lipid lowering therapy Whether endothelial function in the renal vasculature of hypercholesterolemic patients is similarly influenced has not yet been addressed adequately In the present study we investigate whether lipid lowering therapy with rosuvastatin alters renal endothelial function as assessed by systemic infusion of the NO synthase inhibitor L-NMMA after 3 and 42 days of therapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None