Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005321
Status:
COMPLETED
Last Update Posted:
2016-07-12
First Post:
2000-05-25
Brief Title:
Epidemiology of Sleep Disordered Breathing - SCOR in Cardiopulmonary Disorders of Sleep
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To address the public health importance of sleep disordered breathing and ultimately reduce morbidity through information gained from longitudinal population-based epidemiologic studies
Detailed Description:
BACKGROUND
The investigators have shown that undiagnosed sleep disordered breathing is prevalent for both men and women throughout the range of middle age multidisciplinary research findings suggest that untreated sleep disordered breathing may lead to significant behavioral and cardiovascular morbidity The relative risks are of direct application to public health estimates of How much behavioral and cardiovascular morbidity would be eliminated if prevalence of untreated sleep disordered breathing were significantly reduced How much reduction in sleep disordered breathing prevalence could be achieved by eliminating the modifiable etiologic factors Should high risk groups be targeted for early detection of risk factor reduction programs
DESIGN NARRATIVE
The study quantified the etiologic role of hypothesized risk factors for sleep disordered breathing described progression of the pathophysiologic process and tested causal hypotheses of adverse health outcomes The study was conducted on a unique established cohort of over 800 subjects representative of middle-aged employed adults Extensive baseline polysomnographic and other data were available on the established cohort of 800 subjects additional cohorts of 50 perimenopausal women and 200 older adults were added for maximum study power The research resulted in longitudinal data over a 5-9 year period on multiple parameters of sleep breathing risk factors and outcomes The independent relative risks were calculated with multivariate techniques to express the temporal relationships for sleep disordered breathing etiologic factors and for consequences of sleep disordered breathing
The study was renewed in 1993 and used longitudinal studies to focus on specific questions of greatest relevance to public health namely the roles of aging and menopause in the development of sleep-disordered breathing and the effect of sleep disordered breathing on hypersomnolence and systemic hypertension
The study completion date listed in this record was obtained from the Completed Date entered in the Query View Report System QVR
The investigators have shown that undiagnosed sleep disordered breathing is prevalent for both men and women throughout the range of middle age multidisciplinary research findings suggest that untreated sleep disordered breathing may lead to significant behavioral and cardiovascular morbidity The relative risks are of direct application to public health estimates of How much behavioral and cardiovascular morbidity would be eliminated if prevalence of untreated sleep disordered breathing were significantly reduced How much reduction in sleep disordered breathing prevalence could be achieved by eliminating the modifiable etiologic factors Should high risk groups be targeted for early detection of risk factor reduction programs
DESIGN NARRATIVE
The study quantified the etiologic role of hypothesized risk factors for sleep disordered breathing described progression of the pathophysiologic process and tested causal hypotheses of adverse health outcomes The study was conducted on a unique established cohort of over 800 subjects representative of middle-aged employed adults Extensive baseline polysomnographic and other data were available on the established cohort of 800 subjects additional cohorts of 50 perimenopausal women and 200 older adults were added for maximum study power The research resulted in longitudinal data over a 5-9 year period on multiple parameters of sleep breathing risk factors and outcomes The independent relative risks were calculated with multivariate techniques to express the temporal relationships for sleep disordered breathing etiologic factors and for consequences of sleep disordered breathing
The study was renewed in 1993 and used longitudinal studies to focus on specific questions of greatest relevance to public health namely the roles of aging and menopause in the development of sleep-disordered breathing and the effect of sleep disordered breathing on hypersomnolence and systemic hypertension
The study completion date listed in this record was obtained from the Completed Date entered in the Query View Report System QVR
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: