Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00163722
Status:
COMPLETED
Last Update Posted:
2013-02-20
First Post:
2005-09-11
Brief Title:
A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients
Sponsor:
Bayside Health
Organization:
Bayside Health
Study Overview
Official Title:
A Multicentre Randomised Controlled Trial Comparing the Current Standard Diagnostic Strategy for Invasive Aspergillosis to the New Diagnostic Strategy for Invasive Aspergillosis in High-Risk Haematology Patients in Order to Determine Which Strategy Results in the Lower Rates of Use of Empiric Antifungal Therapy
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aspergillus is a fungus found in soil on farms and on construction sites In those whose immune system is impaired it causes severe infection The people who are particularly at high-risk of infection with Aspergillus which is called Invasive Aspergillosisare those with acute leukaemia who are having chemotherapy and those post bone marrow transplantation Currently 15 of those at high-risk develop Invasive Aspergillosis and 60-90 of those with Invasive Aspergillosis die
The main reason for this high death rate is that our current diagnostic tests are not good at detecting infection or often only detect the infection at advanced stages when treatment is ineffective Because of the limitations of current diagnostic tests the current practice is to give empiric antifungal therapy EAFT early to treat suspected Invasive Aspergillosis However studies have demonstrated that this therapy has only resulted in a minor reduction in the mortality rates and it also causes significant drug toxicity It is a suboptimal treatment modality
New tests have recently been developed to diagnose Invasive Aspergillosis These tests are for the detection of an Aspergillus protein in blood and for the detection of Aspergillus DNA in blood Available data suggests that these new tests make an early diagnosis and seem to be able to monitor responses to treatment However no study has been reported to date which demonstrates that the use of these tests can impact on important patient outcomes This trial is being performed to determine whether the use of the new diagnostic tests to guide antifungal therapy will help improve treatment of Invasive Aspergillosis reduce drug toxicity and reduce the death rate in the high-risk patients as compared with the current standard method of diagnosis and treatment with EAFT
The main reason for this high death rate is that our current diagnostic tests are not good at detecting infection or often only detect the infection at advanced stages when treatment is ineffective Because of the limitations of current diagnostic tests the current practice is to give empiric antifungal therapy EAFT early to treat suspected Invasive Aspergillosis However studies have demonstrated that this therapy has only resulted in a minor reduction in the mortality rates and it also causes significant drug toxicity It is a suboptimal treatment modality
New tests have recently been developed to diagnose Invasive Aspergillosis These tests are for the detection of an Aspergillus protein in blood and for the detection of Aspergillus DNA in blood Available data suggests that these new tests make an early diagnosis and seem to be able to monitor responses to treatment However no study has been reported to date which demonstrates that the use of these tests can impact on important patient outcomes This trial is being performed to determine whether the use of the new diagnostic tests to guide antifungal therapy will help improve treatment of Invasive Aspergillosis reduce drug toxicity and reduce the death rate in the high-risk patients as compared with the current standard method of diagnosis and treatment with EAFT
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NHMRC Project Grant 331305 | None | None | None |
| ALLG SC01 | None | None | None |