Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00166166
Status:
TERMINATED
Last Update Posted:
2018-08-15
First Post:
2005-09-13
Brief Title:
Endothelial Hyperpolarization in Humans
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Physiology and Pathologic Role of Endothelium-Derived Hyperpolarizing Factor in Humans
Status:
TERMINATED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Limited clinical staff
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to elucidate the role Endothelium-Derived Hyperpolarizing Factor EDHF plays in dilating blood vessels and whether it differs between healthy people and those with high cholesterol A second purpose of the study is to determine the identity of EDHF
Detailed Description:
The vascular endothelium synthesizes at least four potent vasodilator substances nitric oxide NO prostacyclin carbon monoxide and endothelium-derived hyperpolarizing factor EDHF that contribute to vasodilator tone and to inhibition of platelet activation and inflammation EDHF release is stimulated by receptor-dependent agonists such as acetylcholine and bradykinin BK and leads to hyperpolarization of the underlying smooth muscle cells presumably by opening Ca2-activated K channels Indirect pharmacological evidence suggests that EDHF is a cytochrome P450-derived arachidonic acid metabolite presumably an epoxide Although the pivotal role of NO to conduit vessel dilation in response to acute increases in shear stress is well known its contribution to dilation with sustained increases in flow are minimal and may be due to EDHF release
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 0605-2002 | OTHER | Other | httpsreporternihgovquickSearch1R01HL079115-01 |
| 1R01HL079115-01 | NIH | None | None |