Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001362
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Structural and Functional Imaging of Neurologically Impaired Patients and Normal Volunteers With 15 and 30 Tesla MRI
Status:
COMPLETED
Status Verified Date:
2003-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is divided into two parts The first part of the study will use MRI technology to view the brain structure of patients with neurological disorders and normal volunteers This portion of the study will attempt to detect specific areas of damage in the brains of patients with amnesia and dementia It will also try to correlate the amount of brain damage with performance on tests used to measure memory
In the second part of the study researchers plan to use MRI technology to study brain function of patients with neurological disorders and normal volunteers when they perform tasks MRI signals during task performance will be used to record areas of the brain receiving more blood flow indicating increased activity
Researchers believe this study will help improve existing methods of evaluating patients with neurological disorders In addition this study may contribute information about areas of the brain involved in thought processing and motor and sensory function
In the second part of the study researchers plan to use MRI technology to study brain function of patients with neurological disorders and normal volunteers when they perform tasks MRI signals during task performance will be used to record areas of the brain receiving more blood flow indicating increased activity
Researchers believe this study will help improve existing methods of evaluating patients with neurological disorders In addition this study may contribute information about areas of the brain involved in thought processing and motor and sensory function
Detailed Description:
We wish to use MRI technology to study brain structure Part 1 and function Part 2 in several neurological disorders and in normal controls In Part 1 of this protocol we describe our interest in using detailed MRI brain structure analysis to identify predicted specific neural structure atrophy in patients with selective amnesia and dementia and to attempt to associate the magnitude of atrophy in these neural structures with performance on selected memory tests In Part 2 of this protocol we outline our interest in utilizing newly developed MRI techniques to identify selective changes in local brain blood volume blood flow and other physiological parameters during functional stimulation Recent developments permit recording of MRI signals that are indicative of regional cerebral blood volume and blood flow changes Local changes in these physiological measures appear to topographically overlap with expected areas of functional brain activation The advantage of this method over Positron Emission Tomography is the exquisite spatial resolution of MRI This MRI technique is new and has had only limited use so far The studies in Part 2 of this protocol should help develop the method and begin to answer fundamental biological and functional questions about the representation and activation of cognitive motor and sensory functions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 93-N-0060 | None | None | None |