Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00167427
Status:
COMPLETED
Last Update Posted:
2024-03-07
First Post:
2005-09-09
Brief Title:
Genotoxicity Assessment for Patients Undergoing Radiation Treatment
Sponsor:
Yuhchyau Chen
Organization:
University of Rochester
Study Overview
Official Title:
Genotoxicity Assessment for Patients Receiving Large Field Irradiation
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the research study is to evaluate an automated laser-based technique for measuring DNA damage caused by radiation during cancer treatment in immature red blood cells
Detailed Description:
Correlative studies analysis of RT effect on genotoxicity by assessing cytogenetic changes dicentrics micronucleated lymphocytes MN-lymph and micronucleated reticulocytes MN-RET using peripheral blood of patients receiving radiation
i document the kinetics by which radiation-induced MN-RET enter the peripheral blood stream
ii benchmark the MN-RET endpoint against current gold-standard biodosimetry endpoints-dicentrics and MN-lymphocytes
iii measure inter-individual variation in baseline and radiation-induced MN-RET frequencies
iv in collaboration with several FCM-equipped laboratories evaluate the transferability of the human MN-RET scoring assay
i document the kinetics by which radiation-induced MN-RET enter the peripheral blood stream
ii benchmark the MN-RET endpoint against current gold-standard biodosimetry endpoints-dicentrics and MN-lymphocytes
iii measure inter-individual variation in baseline and radiation-induced MN-RET frequencies
iv in collaboration with several FCM-equipped laboratories evaluate the transferability of the human MN-RET scoring assay
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1U19AI067733-01 | NIH | None | httpsreporternihgovquickSearch1U19AI067733-01 |