Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00162825
Status:
COMPLETED
Last Update Posted:
2008-07-11
First Post:
2005-09-12
Brief Title:
Role of CD7 in Skin Inflammation and Psoriasis
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2003-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Role of CD7 in skin inflammation and psoriasis
Detailed Description:
Psoriasis is a debilitating chronic inflammatory skin disorder characterized by scaly skin patches caused by infiltration of inflammatory cells into the dermis and epidermis with secondary epidermal cell keratinocyte hyperproliferation Psoriasis is a complex disease and a combination of genetic and environmental factors are likely to be causative T-cell-mediated immune process including cytokines eg IFN-γ and chemokines play an essential role in psoriasis Susceptibility genes for psoriasis map to PSORS1 in the HLA region at chromosome 6p21 PSORS2 in the chromosome 17q24-q25 and others
Recently our colleagues in the Academia Sinica and we performed a genome-wide linkage analysis with polymorphic microsatellites in one five-generation affected psoriasis kindred and the result revealed a close linkage at D17S928 close to CD7 CD7 T cells produce IFN-γ when activated and have been located in skin inflammatory lesions Therefore in this study we first want to examine the role of CD7 in skin inflammations conditions CD7 cells will be stimulated by a variety of methods and will be used to treat keratinocyte cultures or be injected intradermally to mice We will watch for skin inflammation and possible proliferation and changes in keratinocytes Possible changes in CD7 function in patients with psoriasis will be explored for example polymorphisms of the CD7 gene may predispose skin inflammation and abnormal interaction with the keratinocytes CD7- T cells which could be derived from CD7 cells and are enriched in skin inflammation lesions secrete the Th2 cytokine IL-5 We are also interested in the mechanism and the consequences of this CD7 shift We hope this study will be helpful in the understanding and management of skin inflammation conditions including psoriasis
Recently our colleagues in the Academia Sinica and we performed a genome-wide linkage analysis with polymorphic microsatellites in one five-generation affected psoriasis kindred and the result revealed a close linkage at D17S928 close to CD7 CD7 T cells produce IFN-γ when activated and have been located in skin inflammatory lesions Therefore in this study we first want to examine the role of CD7 in skin inflammations conditions CD7 cells will be stimulated by a variety of methods and will be used to treat keratinocyte cultures or be injected intradermally to mice We will watch for skin inflammation and possible proliferation and changes in keratinocytes Possible changes in CD7 function in patients with psoriasis will be explored for example polymorphisms of the CD7 gene may predispose skin inflammation and abnormal interaction with the keratinocytes CD7- T cells which could be derived from CD7 cells and are enriched in skin inflammation lesions secrete the Th2 cytokine IL-5 We are also interested in the mechanism and the consequences of this CD7 shift We hope this study will be helpful in the understanding and management of skin inflammation conditions including psoriasis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None