Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00163696
Status:
UNKNOWN
Last Update Posted:
2007-07-26
First Post:
2005-09-11
Brief Title:
Multi Breath Nitrogen Washout MBNW as a Measure of Small Airway Function in Patients With Respiratory Disease
Sponsor:
Bayside Health
Organization:
Bayside Health
Study Overview
Official Title:
Measurements of Inhomogeneity of the Small Airway With Patients With Cystic Fibrosis Asthma and Bronchiolitis Obliterans Syndrome Post Transplant Using the Multi Breath Nitrogen Washout Technique
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The researchers are investigating a novel technique the multi breath nitrogen washout technique to measure airway changes in various respiratory diseases
Detailed Description:
It is well documented that there are significant ventilatory changes in respiratory diseases such as cystic fibrosis asthma and the onset of bronchiolitis obliterans syndrome BOS following chronic rejection of lung transplantation At present we use measures such as spirometry and lung biopsies to determine the changes of airway function and disease severity Our aim is to develop a novel technique called the multi breath nitrogen washout MBNW which we believe is able to measure the inhomogeneity of ventilation in both the larger airways conductive region generation 1 - 16 as well as the smaller airways acinar region 17 - 23 Our belief is that these measurements are much more subtle than current techniques and will be more sensitive in measuring large and small airway changes in disease The MBNW can also give us an insight as to which particular zones of the lung are affected in differing respiratory disease For example it is believed that BOS begins at the distal portion of the lung acinar region and proceeds towards the proximal zone conductive However at present no current techniques can differentiate between damage to the acinar zone and the conductive zone or indeed accurately measure small airway acinar zone function We believe the the MBNW has the capacity to do so
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None