Ignite Creation Date:
2024-05-06 @ 3:06 AM
Last Modification Date:
2024-10-26 @ 11:28 AM
Study NCT ID:
NCT02206451
Status:
COMPLETED
Last Update Posted:
2019-12-17
First Post:
2014-07-31
Brief Title:
Assessing Human-to-Mosquito Transmission in Volunteers Participating in Malaria Vaccine Candidate Trials in Mali
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Assessing Human-to-Mosquito Transmission in Volunteers Participating in Malaria Vaccine Candidate Trials in DonSqrRootCopyrightguSqrRootCopyrightBougou Mali
Status:
COMPLETED
Status Verified Date:
2016-06-29
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
- Malaria is a disease that affects many people in Mali and in Africa It is caused by germs that are spread by mosquito bites Researchers are creating vaccines that they hope will prevent malaria infection andor the spread of it
Objective
- To test if the PfSPZ vaccine can stop malaria spread by mosquitoes
Eligibility
- People currently enrolled in the ongoing PfSPZ malaria vaccine trial Participants must be willing to have uninfected mosquitoes bite them
Design
Participants will be able to take part in this study at every visit after receiving all scheduled vaccinations
Participants will be asked whether they are willing to participate in the procedures Female participants will have a pregnancy test
Researchers will put about 60 mosquitoes in 2 or 3 cups 20 or 30 in each cup They will hold each cup to the participant s leg or arm so the mosquitoes can bite These mosquitoes do not carry germs and will take about 3 drops of blood total
Participants will get a cream for any swelling or itching
Participants will be checked the next day for any discomfort
Participants may take part in this feeding test multiple times if they are willing
If participants have malaria parasites in their blood they may be asked to take part in another study For this they will sleep alone in their hut the night after the feeding test A study team will set up nets to collect mosquitoes that may have bitten the participant overnight
- Malaria is a disease that affects many people in Mali and in Africa It is caused by germs that are spread by mosquito bites Researchers are creating vaccines that they hope will prevent malaria infection andor the spread of it
Objective
- To test if the PfSPZ vaccine can stop malaria spread by mosquitoes
Eligibility
- People currently enrolled in the ongoing PfSPZ malaria vaccine trial Participants must be willing to have uninfected mosquitoes bite them
Design
Participants will be able to take part in this study at every visit after receiving all scheduled vaccinations
Participants will be asked whether they are willing to participate in the procedures Female participants will have a pregnancy test
Researchers will put about 60 mosquitoes in 2 or 3 cups 20 or 30 in each cup They will hold each cup to the participant s leg or arm so the mosquitoes can bite These mosquitoes do not carry germs and will take about 3 drops of blood total
Participants will get a cream for any swelling or itching
Participants will be checked the next day for any discomfort
Participants may take part in this feeding test multiple times if they are willing
If participants have malaria parasites in their blood they may be asked to take part in another study For this they will sleep alone in their hut the night after the feeding test A study team will set up nets to collect mosquitoes that may have bitten the participant overnight
Detailed Description:
A vaccine which interrupts malaria transmission VIMT is a critical tool to achieve the ultimate goal of eradication of this disease VIMTs work by inducing humoral responses in vaccinated individuals that inhibit the development of malaria parasites in the mosquito and combined humoral and cellular responses that inhibit the establishment of infection in humans Overall efficacy of these vaccines is evaluated by measuring reduction of infection and clinical cases among vaccinees and the parasite infectivity to mosquitoes human-to-mosquito transmissibility before and after vaccination and with or without vaccination One of the candidate VIMTs the PfSPZ Vaccine is currently being tested in Mali for safety tolerance and immunogenicity
The objective of this Feeding Assay Protocol is to explore the effect of the PfSPZ Vaccine on interrupting human-to-mosquito transmission Individuals from the the PfSPZ Vaccine trial in 2014 who also consent to be enrolled in this Feeding Assay Protocol will be eligible to participate in procedures including direct skin feeds DSF and experimental huts EH The human-to-mosquito transmission will be evaluated by examining the presence of malaria parasites in the midgut of mosquitoes fed on study participants The human-to-mosquito transmission by DSF and EH assay methods will be analyzed for potential correlation
The objective of this Feeding Assay Protocol is to explore the effect of the PfSPZ Vaccine on interrupting human-to-mosquito transmission Individuals from the the PfSPZ Vaccine trial in 2014 who also consent to be enrolled in this Feeding Assay Protocol will be eligible to participate in procedures including direct skin feeds DSF and experimental huts EH The human-to-mosquito transmission will be evaluated by examining the presence of malaria parasites in the midgut of mosquitoes fed on study participants The human-to-mosquito transmission by DSF and EH assay methods will be analyzed for potential correlation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 14-I-N159 | None | None | None |