Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00164892
Status:
UNKNOWN
Last Update Posted:
2005-11-17
First Post:
2005-09-12
Brief Title:
Selective COX-II Inhibitor as an Adjuvant Therapy in Patients With Resectable Advanced Stomach Cancer Histological Staging T2N1 - A Multi-Centre Prospective Randomised Controlled Trial
Sponsor:
Chinese University of Hong Kong
Organization:
Chinese University of Hong Kong
Study Overview
Official Title:
Selective COX-II Inhibitor as an Adjuvant Therapy in Patients With Resectable Advanced Stomach Cancer Histological Staging T2N1 - A Multi-Centre Prospective Randomised Controlled Trial
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the efficacy of selective COX-II inhibitor in patients with curative resection performed for locally advanced stomach cancer
Detailed Description:
Cyclo-oxygenase COX is a family of enzymes regulating the conversion of arachidonic acid to prostaglandins COX-II is an inducible enzyme which may be upregulated when there are stimuli such as inflammation or hypergastrinaemia Despite radical surgery patients with stomach cancer of advanced stages often have a poor prognosis Reported survival in those with diseases of stage IIIa or above is less than 40 Methods to improve patients outcome have been explored for decades with little success In the light of current understanding on the relation between COX-II and stomach cancer selective COX-II inhibitor may be used as a novel adjuvant therapy after gastrectomy to prevent recurrence of gastric carcinoma The advantages of COX-II inhibitors are being relatively non-toxic with minimal side effect
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None