Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172640
Status:
UNKNOWN
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
Genetic Studies in Liver Cancer Patients
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Identification of Differentially Expressed Genes in Hepatocellular Carcinoma With DNA Microarrays
Status:
UNKNOWN
Status Verified Date:
2004-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hepatocellular carcinoma HCC is one the most common malignancies in the world especially in sub-Saharan Africa and Southeast Asia Since 1984 it has been the leading cause of cancer death in Taiwan About 6000-8000 people died of this cancer every year in Taiwan DNA microarray DNA chip is a very powerful tool to clarify the genetic changes in cancers Expression profiling techniques have been used to simultaneously monitor the expression of thousands of genes from human tumor samples It has been successfully used to predict clinical outcome and survival as well as classify different types of cancer In this study we will use the DNA chip to study the genetics in liver cancer patients
Detailed Description:
The clinical samples will be collected in the NTUH while the DNA microarray works will be done in Biomedical Engineering Center BMEC of ITRI
Patients A total of 40 cases of HCC patients 20 HBV-related HCC and 20 HCV-related HCC who received surgical resection in National Taiwan University Hospital will be enrolled from our tissue banks The diagnosis of HCC was confirmed by pathological examination The surgical specimens were frozen immediately after surgery and stored in -140C The clinicopathological data will be retrospectively obtained from chart reviews
Another total of 40 new HCC patients who receive surgical resection in National Taiwan University Hospital will be collected The healthy subjects and patients chronically infected with HBV or HCV without HCC will be used as controls The whole bloods will be collected before one and six months after operation The diagnosis of HCC will be confirmed by pathology In addition to the whole bloods the surgical specimens will be frozen immediately after surgery and stored in -140C
Patients A total of 40 cases of HCC patients 20 HBV-related HCC and 20 HCV-related HCC who received surgical resection in National Taiwan University Hospital will be enrolled from our tissue banks The diagnosis of HCC was confirmed by pathological examination The surgical specimens were frozen immediately after surgery and stored in -140C The clinicopathological data will be retrospectively obtained from chart reviews
Another total of 40 new HCC patients who receive surgical resection in National Taiwan University Hospital will be collected The healthy subjects and patients chronically infected with HBV or HCV without HCC will be used as controls The whole bloods will be collected before one and six months after operation The diagnosis of HCC will be confirmed by pathology In addition to the whole bloods the surgical specimens will be frozen immediately after surgery and stored in -140C
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None