Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172354
Status:
COMPLETED
Last Update Posted:
2012-12-03
First Post:
2005-09-12
Brief Title:
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
Status:
COMPLETED
Status Verified Date:
2012-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Out-of-hospital cardiac arrest OHCA is an important issue for the emergency physicians and co-workers How to improve the return of spontaneous circulation ROSC rate and prognosis of these patients challenges the emergency team When encounters stress the hypothalamus of human releases corticotropin releasing hormone which in turn stimulates the pituitary gland to release ACTH Then ACTH acts on the adrenal gland to release glucocorticoid to against stress Foley PJ et al found the dogs with bilateral adrenalectomy had lower ROSC rate during resuscitation than those without surgery1 Karl H Linder et al showed OHCA patients had high serum vasopressin and ACTH level but low serum cortisol level Besides the serum cortisol level had a negative correlation with collapse duration no CPR duration2 Studies also revealed the successfully resuscitated patients had higher serum ACTH and cortisol level than non-resuscitated ones23 In addition the serum cortisol level was found to be correlated with short term survival rate and hemodynamic status in resuscitated OHCA patients3 Animal study also showed mice receiving higher dosage of hydrocortisone had higher ROSC rate and lower epinephrine requirement than those receiving lower dosage of hydrocortisone or normal saline
Reference
1 Foley PJ Tacker WA Wortsman J Frank S Cryer PE Plasma catecholamine and serum cortisol responses to experimental cardiac arrest in dogsAm J Physiol 1987253E283-9
2 Lindner KH Strohmenger HU Ensinger H Hetzel WD Ahnefeld FW Georgieff M Stress hormone response during and after cardiopulmonary resuscitationAnesthesiology 199277662-8
3 Schultz CH Rivers EP Feldkamp CS Goad EG Smithline HA Martin GB Fath JJ Wortsman J Nowak RMA characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrestCrit Care Med 1993211339-47
4 Smithline H Rivers E Appleton T Nowak RCorticosteroid supplementation during cardiac arrest in ratsResuscitation 199325257-64
Reference
1 Foley PJ Tacker WA Wortsman J Frank S Cryer PE Plasma catecholamine and serum cortisol responses to experimental cardiac arrest in dogsAm J Physiol 1987253E283-9
2 Lindner KH Strohmenger HU Ensinger H Hetzel WD Ahnefeld FW Georgieff M Stress hormone response during and after cardiopulmonary resuscitationAnesthesiology 199277662-8
3 Schultz CH Rivers EP Feldkamp CS Goad EG Smithline HA Martin GB Fath JJ Wortsman J Nowak RMA characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrestCrit Care Med 1993211339-47
4 Smithline H Rivers E Appleton T Nowak RCorticosteroid supplementation during cardiac arrest in ratsResuscitation 199325257-64
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None