Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172952
Status:
UNKNOWN
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
The Role of SNP of ECM and MMP on the Development of Pathological High Myopia
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
National Taiwan University Hospital
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the clinical characteristics and inheritance of pathological myopia in Taiwanese patients
Detailed Description:
High myopia pathological myopia is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole Pathological myopia often accompanied by glaucoma cataracts macular degeneration and retinal detachment leading to blindness when the damage to the retina is extremely severe Population and family studies in Chinese have provided evidence for a geneticcomponent to pathologic myopia Children of myopic parents are more likely to have myopia than are children of nonmyopic parents Therefore it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia The retina receives the signal from the retina-RPE complexes and affects the growth of scleral coats The changes of scleral components collagen fibrils and proteoglycans are noted in experimental and human myopia and induce the pathology of high myopia It is interesting to know that individual difference of SNP in the components of scleral coat affects the response to the signal from retina-RPE complexes The most important effectors in scleral coats are collagens proteoglycans MMPs and TIMPs Therefore the difference of SNPs in different genes might contribute the formation of scleral thinning during myopia development In this project we will focus on this subject by using GenomeLab SNPstream Genotyping System which is powerful and helpful for identify some specific SNPs in the regard
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None