Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00177645
Status:
COMPLETED
Last Update Posted:
2023-09-07
First Post:
2005-09-13
Brief Title:
Inhaled Bicarbonate Therapy in Cystic Fibrosis
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Inhaled Bicarbonate Therapy in Cystic Fibrosis
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to see if inhaled bicarbonate will increase the ability to cough up mucus in a person with cystic fibrosis
Detailed Description:
There is evidence that people with CF may have differences in the liquid that lines the surface of their lungs from people without CF There are two things that are known to be different One is called bicarbonate secretion which is the movement of a salt called bicarbonate that is normally present in the blood and lung fluid in all people The abnormal movement of bicarbonate appears to cause a second abnormality - the liquid in the breathing tubes has more acid than the liquid in patients without CF These differences may affect the stickiness and thickness of the mucus and limit how well the hairs that line the breathing tubes cilia move mucus out of the lungs
Recent studies in a group of patients with chronic cough looked at the effects of giving an inhaled bicarbonate solution sodium bicarbonate instead of sodium chloride on the study subjects ability to cough up mucus Compared to the group given inhaled saline the patients given inhaled bicarbonate were able to cough up approximately three times as much mucus No clinical studies have looked at whether inhaled bicarbonate improves the ability of the lung in a person with CF to move mucus out of the lung or how this treatment affects lung function in patients with CF
Recent studies in a group of patients with chronic cough looked at the effects of giving an inhaled bicarbonate solution sodium bicarbonate instead of sodium chloride on the study subjects ability to cough up mucus Compared to the group given inhaled saline the patients given inhaled bicarbonate were able to cough up approximately three times as much mucus No clinical studies have looked at whether inhaled bicarbonate improves the ability of the lung in a person with CF to move mucus out of the lung or how this treatment affects lung function in patients with CF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None