Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172406
Status:
COMPLETED
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
The Relation Between Serum Level of Amioterminal Propeptide of Type I Procollagen and Diastolic Dysfunction in Hypertensive Patients Without Diabetes Mellitus
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the present study we assessed the relation between diastolic dysfunction and myocardial fibrosis in hypertensive patients without diabetes mellitus A total of 20 medically treated ambulatory non-diabetic hypertensive patients with normal left ventricular LV systolic function were enrolled into this study Myocardial fibrosis was evaluated by serum concentrations of amino-terminal propeptides of type I and III procollagen PINP and PIIINP All patients underwent examinations of diastolic function by echocardiography and technetium-99m 99mTc radionuclide ventriculography There were 8 patients with PINP 53 μgl group 1 and 12 patients with PINP 53 μgl group 2 Patients in group 2 had significantly lower LV peak filling rate PFR 32 03 vs 25 02 end-diastolic volumes and shorter time to PFR 257 41 vs 174 22 ms Besides the group 2 patients also had lower right ventricle PFR 19 02 vs 15 01 end-diastolic volumes and shorter time to PFR 221 29 vs 154 29 ms Echocardiographic parameters for LV diastolic dysfunction EA ratio of mitral flow deceleration time of E flow velocities of pulmonary venous flow retrograde A wave systolic diastolic velocity ratio isovolumetric relaxation time Tei index were all comparable between two groups In multiple regression analysis LV time to peak filling rate was the only parameter that independently predicted serum PINP level p005 In conclusion elevated serum PINP level reflected LV diastolic dysfunction in hypertensive patients without diabetes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None