Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00170196
Status:
COMPLETED
Last Update Posted:
2008-09-29
First Post:
2005-09-12
Brief Title:
Efficacy Studies of Corticosteroid Therapy in Community-Acquired Pneumonia
Sponsor:
Medical Center Alkmaar
Organization:
Medical Center Alkmaar
Study Overview
Official Title:
The CAPISCE-Trial Community-Acquired Pneumonia an Intervention Study With Corticosteroids
Status:
COMPLETED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the efficacy of addition of corticosteroid therapy to antibiotics in patient admitted with Community-acquired pneumonia
The hypothesis is Prednisolone in combination with antibiotic treatments is effective in improving clinical outcome in patients hospitalized with CAP
The hypothesis is Prednisolone in combination with antibiotic treatments is effective in improving clinical outcome in patients hospitalized with CAP
Detailed Description:
Community-acquired pneumonia CAP is a acute illness with a considerable morbidity and mortality especially patients with severe CAP In the past decennia in spite of many investigations little reduction is seen in morbidity an mortality Corticosteroids have a immune-modulation effect which is not completely elucidated Most likely the immune modulation effect is due to down-regulation of pro-inflammatory cytokines The use of corticosteroids next to antibiotics in CAP could lead to shorter time to clinical stability length of stay and costs
Comparison Hospitalized patients with CAP treated with antibiotics and prednisolone versus hospitalized patients with cap treated with antibiotics and placebo
Comparison Hospitalized patients with CAP treated with antibiotics and prednisolone versus hospitalized patients with cap treated with antibiotics and placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None