Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00179400
Status:
COMPLETED
Last Update Posted:
2020-09-11
First Post:
2005-09-13
Brief Title:
Insulin Action in Individuals With Type 2 Diabetes by Natural Fatty Acids or the Medication Pioglitazone
Sponsor:
Albert Einstein College of Medicine
Organization:
Albert Einstein College of Medicine
Study Overview
Official Title:
The Role of Acute Combined Peroxisome Proliferator-Activated Receptors PPAR Alpha and Gamma Stimulation on Insulin Action in Humans
Status:
COMPLETED
Status Verified Date:
2020-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the changes in insulin a hormone produced in the body by the pancreas that regulates the amount of sugar in the blood action and adiponectin a protein hormone which regulates sugar levels and fatty acid breakdown levels after giving individuals with type 2 diabetes a medication pioglitazone for three weeks
Detailed Description:
Participants in this study will be given a 21 day supply of either pioglitazone a medication used to treat diabetes or a placebo Changes to the bodys response to insulin in the liver and in peripheral tissues eg muscle and fat will be measured using a procedure called a pancreatic clamp During the clamp procedure glucose a sugar and insulin are infused with an intravenous catheter and blood samples are collected periodically throughout the procedure to measure blood sugar levels and the levels of several hormones that are found in the body and are related to glucose metabolism Small amounts of muscle and fat tissue will also be taken during this study to measure changes in gene expression after taking the medicationplacebo for 3 weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None