Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004793
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2000-02-24
Brief Title:
Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children
Sponsor:
National Center for Research Resources NCRR
Organization:
Office of Rare Diseases ORD
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Evaluate the effect of bromocriptine on luteinizing hormone LH secretion by suppression of prolactin and stimulation of dopaminergic receptors in early pubertal boys and girls
II Evaluate the effect of baclofen on LH secretion by stimulation of gamma-aminobutyric acid receptors in early pubertal boys and girls
II Evaluate the effect of baclofen on LH secretion by stimulation of gamma-aminobutyric acid receptors in early pubertal boys and girls
Detailed Description:
PROTOCOL OUTLINE
Participants receive bromocriptine or baclofen followed by nocturnal measurements of luteinizing hormone growth hormone and sex steroids Pituitary reserve is evaluated with the administration of gonadotropin-releasing hormone and in children undergoing assessment of short stature standard provocative stimuli
Participants receive bromocriptine or baclofen followed by nocturnal measurements of luteinizing hormone growth hormone and sex steroids Pituitary reserve is evaluated with the administration of gonadotropin-releasing hormone and in children undergoing assessment of short stature standard provocative stimuli
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UMMC-1354 | None | None | None |