Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00178087
Status:
COMPLETED
Last Update Posted:
2015-04-07
First Post:
2005-09-13
Brief Title:
Determining Changes in Brain Structure Associated With Symptoms of Late-life Depression
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Pathways Linking Late-Life Depression to MCI Dementia
Status:
COMPLETED
Status Verified Date:
2015-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression
Detailed Description:
The goal of this research study is to investigate the relationships among late-life depression LLD cognitive impairment and progressive neurodegeneration The guiding hypothesis is that LLD patients have evolving cognitive impairments as a consequence of distinct underlying neuropathological changes which frequently are expressed as Mild Cognitive Impairment MCI These neuropathological and cognitive changes are risk modifiers lowering brain reserve capacity and in turn increasing risk of developing Alzheimers Disease AD In order to pursue this goal we will enroll LLD MCI and normal control subjects to enrich our existing cohort to include a total of 150 elderly non-demented non-depressed subjects 60 non-depressed MCI subjects and 270 LLD subjects Using the joint infrastructure of the University of Pittsburghs Advanced Center for Intervention and Services Research for Late-Life Mood Disorders and the Alzheimers Disease Research Center we will complete a detailed neurobehavioral evaluation including clinical neuropsychological neuroimaging and biological markers using these data to evaluate the factors associated with the development of MCI or dementia Subjects will be studied annually for at least three years allowing us to use longitudinal data to evaluate a series of linked hypotheses that postulate the pathways by which elderly depressed patients develop cognitive impairment and which may lead some to develop dementia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DATR A4-GPT | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH072947 |
| R01MH072947 | NIH | None | None |
| 9512127 | None | None | None |