Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173433
Status:
COMPLETED
Last Update Posted:
2014-12-09
First Post:
2005-09-12
Brief Title:
Exogenous Reinfection of Tuberculosis in Taiwan
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
The Importance of Exogenous Reinfection in the Tuberculosis Endemic of Taiwan
Status:
COMPLETED
Status Verified Date:
2014-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
we hypothesize that exogenous reinfection is very important in the Taiwan endemic Therefore we design a series of studies to evaluate the individual contribution of exogenous reinfection and endogenous reactivation in the Taiwan endemic and to realize the impact of exogenous reinfection First we will identify the patients with TB relapse after complete treatment The M tuberculosis isolates responsible for their initial and recurrent episodes will then be genotyped to clarify the percentage of exogenous reinfection and endogenous reinfection
Detailed Description:
Tuberculosis TB remains the most important infectious disease in the world In Taiwan the incidence of TB increased in recent years The failure of control implies the necessity to reevaluate the epidemiology of Mycobacterium tuberculosis It is widely thought that most cases of TB are caused by reactivation of a latent infection Treatment programs have therefore focused on cure rates rather than tracking of additional cases But recent studies showed that exogenous reinfection plays an important role in the development of TB In addition it seems that the higher the local incidence the more important exogenous reinfection is The question of exogenous reinfection versus endogenous reactivation has an impact on the distribution of resources for the prevention and treatment of TB Based on these evidences we hypothesize that exogenous reinfection is very important in the Taiwan endemic Therefore we design a series of studies to evaluate the individual contribution of exogenous reinfection and endogenous reactivation in the Taiwan endemic and to realize the impact of exogenous reinfection First we will identify the patients with TB relapse after complete treatment The M tuberculosis isolates responsible for their initial and recurrent episodes will then be genotyped to clarify the percentage of exogenous reinfection and endogenous reinfection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None