Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00177099
Status:
COMPLETED
Last Update Posted:
2006-11-13
First Post:
2005-09-13
Brief Title:
Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice
Sponsor:
Hordinsky Maria K MD
Organization:
University of Minnesota
Study Overview
Official Title:
Neurotrophic Effects of Immunophilin Ligands on Human Hair Follicles Grafted Onto Service Combined Immunodeficient SCID Mice
Status:
COMPLETED
Status Verified Date:
2006-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if immunophilin ligands may have the potential to reverse hair loss
Detailed Description:
Preliminary experiments in C57BL6J mice showed that immunophilin ligand FK506 and its non-immunosuppressive analogs GP11046 and GP11511 were capable of promoting telogen to anagen transition Since GP11046 and GP11511 possess the neurotrophic properties of FK506 without its immunosuppressant capability the neural action of these immunophilin ligands may play an important role in the hair cycle This finding has significant clinical implications in that immunophilin ligands may have the potential to reverse alopecia To further investigate this possibility we propose to explore the response of transplanted miniaturized scalp hair follicles to topically applied immunophilin ligands
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None