Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173238
Status:
UNKNOWN
Last Update Posted:
2005-12-21
First Post:
2005-09-12
Brief Title:
The Study of Human Atherosclerosis by Polarization-Sensitive Optical Coherence Tomography
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Atherosclerosis is unquestionably the leading cause of morbidity and mortality in developed countries and the world-wide importance of acute vascular syndromes is increasing Rupture of atherosclerotic plaque has been identified as the proximate event in the majority of cases of acute ischemic syndromes Therefore modalities capable of characterizing the atherosclerotic lesion may be helpful in understanding its natural history and detecting lesions with high risk for acute events
Optical coherence tomography OCT is a powerful tool capable of tomographic imaging based on low coherence interferometry It is analogous to ultrasound imaging except that it uses infrared light instead of sound Polarization-sensitive optical coherence tomography PS-OCT combines the advantages of OCT with additional image contrast of the sample The added contrast is based on the ability of PS-OCT to detect the birefringent properties of a sample phase retardation and fast-axis orientation simultaneously
The goals of this project are 1 to examine whether PS-OCT is an acceptable tool for the characterization of typical plaque constituents and 2 to explain the correlation between birefringence and forming or rupture of a plaque and 3 to establish a quantitative PS-OCT image criteria for atherosclerotic plaque characterization in vitro
Optical coherence tomography OCT is a powerful tool capable of tomographic imaging based on low coherence interferometry It is analogous to ultrasound imaging except that it uses infrared light instead of sound Polarization-sensitive optical coherence tomography PS-OCT combines the advantages of OCT with additional image contrast of the sample The added contrast is based on the ability of PS-OCT to detect the birefringent properties of a sample phase retardation and fast-axis orientation simultaneously
The goals of this project are 1 to examine whether PS-OCT is an acceptable tool for the characterization of typical plaque constituents and 2 to explain the correlation between birefringence and forming or rupture of a plaque and 3 to establish a quantitative PS-OCT image criteria for atherosclerotic plaque characterization in vitro
Detailed Description:
Optical Coherence Tomography OCT is a promising new class of diagnostic medical imaging technology that utilizes advanced photonics and fiber optics to obtain images and tissue characterization on a scale never before possible within the human body OCT combines the principles of ultrasound with the imaging performance of a microscope and a form factor that is familiar to clinicians Whereas ultrasound produces images from backscattered sound echoes OCT uses infrared light waves that reflect off the internal microstructure within the biological tissues
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None