Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00175084
Status:
COMPLETED
Last Update Posted:
2014-05-23
First Post:
2005-09-08
Brief Title:
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism Vascular Reactivity and Inflammatory Markers
Sponsor:
Tufts University
Organization:
Tufts University
Study Overview
Official Title:
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism Vascular Reactivity and Inflammatory Markers
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to explore the significance of the LysArg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary LysArg on cardiovascular disease risk factors and endothelial function
Detailed Description:
Findings from early studies in a variety of experimental models of atherosclerosis on the effect of dietary protein suggested that proteins from vegetable sources are less cholesterolemic and atherogenic than proteins from animal sources Throughout the later part of the 20th century there has been sporadic interest in the effect of protein type and amino acid profiles on blood lipid concentrations and atherosclerosis A major focus for this evaluation has been to compare proteins based on their amino acid profile often expressed as lysine Lys to arginine Arg ratio LysArg While animal studies have provided important information regarding the significance of the LysArg in determining the cholesterolemic response to a dietary protein interpretation of these data must be done with caution since most of the studies have been conducted in animal models that have a different lipoprotein distribution and metabolism than humans Moreover the mechanistic insights of this response are yet to be determined While the favorable effects of Arg on endothelial function appear to be consistent when Arg is administered using a supplement the effects of dietary Arg naturally present in protein rich foods has yet to be determined The aim of this proposal is to explore the significance of the LysArg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary LysArg on cardiovascular disease risk factors and endothelial function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None