Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00178074
Status:
COMPLETED
Last Update Posted:
2013-08-02
First Post:
2005-09-13
Brief Title:
The Effects of Sleep Deprivation on Antidepressant Response
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
The Effects of Sleep Deprivation on Antidepressant Response in Geriatric Depression Neurometabolic Substrates Studied With PET
Status:
COMPLETED
Status Verified Date:
2013-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use positron emission tomography PET to examine the effect of sleep deprivation on brain function
Detailed Description:
This study seeks to better understand the effect of sleep deprivation TSD on brain function using Positron Emission Tomography PET PET is an established research procedure that produces images of the brain The purpose of these images is to show changes in brain activity associated with sleep deprivation The neurochemical mechanisms underlying the TSD acceleration of antidepressant efficacy have not been identified An understanding of these neurochemical processes may lead to the development of pharmacologic strategies that would accelerate antidepressant response or more directly to the development of antidepressant treatments that are more efficacious
This study will be conducted in collaboration with Dr Charles Reynolds ongoing protocol Geriatric Depression Neurobiology of Treatment IRB 970356 The impetus for the clinical studies is the finding that the clinical response to antidepressant treatment in geriatric depressed patients is delayed with the median time to remission reported as up to 12 weeks Thus the development of a strategy to accelerate treatment response would represent a substantial contribution to the treatment of geriatric depression One approach that has been reported to accelerate antidepressant response in mid-life depression is one night of total sleep deprivation TSD prior to initiating antidepressant treatment TSD has also been shown to improve mood in depressed patients the response to TSD may distinguish subsequent treatment responders from non-responders and depressive relapse may occur after naps or a night of recovery sleep The neurochemical mechanisms underlying the TSD acceleration of antidepressant efficacy have not been identified An understanding of these neurochemical processes may lead to the development of pharmacologic strategies that would accelerate antidepressant response or more directly to the development of antidepressant treatments that are more efficacious
Advancements in brain imaging technology and radiotracer chemistry have made it possible to measure metabolic activity and specific neurochemical mechanisms using Positron Emission Tomography PET The proposed studies represent the initial step in characterizing the neurochemical alterations produced by TSD and the impact of TSD on antidepressant response by TSD in geriatric depressed patients using PET and a radiotracer for brain glucose metabolism 18F-2deoxy-2-fluoro-D-glucose 18F-2DG Having established the regional metabolic alterations associated with sleep deprivation and recovery sleep in patients who are subsequent treatment responders and compared the metabolic changes with treatment non-responders future studies will be undertaken using neuroreceptor radiotracers to define the specific neurochemical pathways subserving the regional pattern of metabolic alterations The glucose metabolic response to sleep deprivation in mid-life depression has been investigated at the UPMC PET Facility and at other institutions eg Dube et al in preparation Wu et al 1991 1992 The studies performed in the geriatric depressed patients will be compared with the PET studies conducted in mid-life depressed patients to assess the contribution of the aging process to the neurometabolic response to sleep
For information on related studies please follow these links
httpclinicaltrialsgovshowNCT00177294
httpclinicaltrialsgovshowNCT00178035
This study will be conducted in collaboration with Dr Charles Reynolds ongoing protocol Geriatric Depression Neurobiology of Treatment IRB 970356 The impetus for the clinical studies is the finding that the clinical response to antidepressant treatment in geriatric depressed patients is delayed with the median time to remission reported as up to 12 weeks Thus the development of a strategy to accelerate treatment response would represent a substantial contribution to the treatment of geriatric depression One approach that has been reported to accelerate antidepressant response in mid-life depression is one night of total sleep deprivation TSD prior to initiating antidepressant treatment TSD has also been shown to improve mood in depressed patients the response to TSD may distinguish subsequent treatment responders from non-responders and depressive relapse may occur after naps or a night of recovery sleep The neurochemical mechanisms underlying the TSD acceleration of antidepressant efficacy have not been identified An understanding of these neurochemical processes may lead to the development of pharmacologic strategies that would accelerate antidepressant response or more directly to the development of antidepressant treatments that are more efficacious
Advancements in brain imaging technology and radiotracer chemistry have made it possible to measure metabolic activity and specific neurochemical mechanisms using Positron Emission Tomography PET The proposed studies represent the initial step in characterizing the neurochemical alterations produced by TSD and the impact of TSD on antidepressant response by TSD in geriatric depressed patients using PET and a radiotracer for brain glucose metabolism 18F-2deoxy-2-fluoro-D-glucose 18F-2DG Having established the regional metabolic alterations associated with sleep deprivation and recovery sleep in patients who are subsequent treatment responders and compared the metabolic changes with treatment non-responders future studies will be undertaken using neuroreceptor radiotracers to define the specific neurochemical pathways subserving the regional pattern of metabolic alterations The glucose metabolic response to sleep deprivation in mid-life depression has been investigated at the UPMC PET Facility and at other institutions eg Dube et al in preparation Wu et al 1991 1992 The studies performed in the geriatric depressed patients will be compared with the PET studies conducted in mid-life depressed patients to assess the contribution of the aging process to the neurometabolic response to sleep
For information on related studies please follow these links
httpclinicaltrialsgovshowNCT00177294
httpclinicaltrialsgovshowNCT00178035
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DATR A4-GPS | None | None | None |
| 980753 | None | None | None |