Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005751
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Endothelial Vasomotor Function in the Framingham Study
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether the presence of endothelial dysfunction is an independent risk factor for cardiovascular disease events
Detailed Description:
BACKGROUND
Current research suggests that loss of the vasodilator anti-thrombotic and anti-inflammatory properties of the vascular endothelium plays a dynamic role in the pathogenesis of cardiovascular disease Impaired endothelial function including impaired nitric oxide-dependent vasodilation is associated with cardiovascular disease risk factors Further there is growing evidence that endothelial function can be improved by risk modification However the available studies have not definitively resolved the issue of the cross-sectional correlates of endothelial dysfunction because they have been limited to small samples of highly selected patients For example it remains unclear whether hypercholesterolemia hypertension or elevated glucose levels are independent determinants of endothelial dysfunction Most importantly no study has shown a relation between endothelial dysfunction and increased cardiovascular risk Such a demonstration would increase our understanding of the pathogenesis of cardiovascular disease and aid clinicians in identifying high risk individuals who would benefit most from intervention
DESIGN NARRATIVE
Using non-invasive brachial artery ultrasound endothelial function was examined in about 3800 men and women of the Framingham Heart Study The cross-sectional correlates of endothelial function with known coronary risk factors were examined and cross-sectional analyses were performed on the relation of endothelial function to prevalent cardiovascular disease Observations were made of the adjusted relation of endothelial function to incident and recurrent cardiovascular events The central hypothesis was that the presence of endothelial dysfunction was an independent risk factor for cardiovascular disease events
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Current research suggests that loss of the vasodilator anti-thrombotic and anti-inflammatory properties of the vascular endothelium plays a dynamic role in the pathogenesis of cardiovascular disease Impaired endothelial function including impaired nitric oxide-dependent vasodilation is associated with cardiovascular disease risk factors Further there is growing evidence that endothelial function can be improved by risk modification However the available studies have not definitively resolved the issue of the cross-sectional correlates of endothelial dysfunction because they have been limited to small samples of highly selected patients For example it remains unclear whether hypercholesterolemia hypertension or elevated glucose levels are independent determinants of endothelial dysfunction Most importantly no study has shown a relation between endothelial dysfunction and increased cardiovascular risk Such a demonstration would increase our understanding of the pathogenesis of cardiovascular disease and aid clinicians in identifying high risk individuals who would benefit most from intervention
DESIGN NARRATIVE
Using non-invasive brachial artery ultrasound endothelial function was examined in about 3800 men and women of the Framingham Heart Study The cross-sectional correlates of endothelial function with known coronary risk factors were examined and cross-sectional analyses were performed on the relation of endothelial function to prevalent cardiovascular disease Observations were made of the adjusted relation of endothelial function to incident and recurrent cardiovascular events The central hypothesis was that the presence of endothelial dysfunction was an independent risk factor for cardiovascular disease events
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL060040 | NIH | None | httpsreporternihgovquickSearchR01HL060040 |