Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173459
Status:
COMPLETED
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
Dynamic Profiles of CytokineChemokine in Severe Acute Respiratory Syndrome
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Severe acute respiratory syndrome SARS is an emerging infectious disease caused by a novel coronavirus SARS-CoV The major clinical features of SARS include fever dyspnea lymphopenia and a rapid progression of pulmonary infiltrates on chest radiologic images The SARS-related deaths have resulted mainly from pulmonary complications including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome ARDS Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage We therefore undertook an analysis of dynamic production of cytokinechemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient management
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None