Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00182156
Status:
WITHDRAWN
Last Update Posted:
2022-04-15
First Post:
2005-09-10
Brief Title:
Cohort Study Comparing Short Daily Hemodialysis HD With Conventional HD
Sponsor:
McMaster University
Organization:
McMaster University
Study Overview
Official Title:
Cohort Study Examining the Effects of Short Daily Hemodialysis As Compared to Conventional Hemodialysis in Outpatients Treated at St Josephs Healthcare Hamilton
Status:
WITHDRAWN
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is examining the effects of short daily hemodialysis on platelet function fluid volume control arterial stiffness and patient quality of life as compared to conventional hemodialysis
Detailed Description:
Bleeding is a common cause of morbidity and mortality in patients with end stage renal disease A major cause of uremic bleeding is due to platelet dysfunction It has been theorized that in renal failure toxins accumulate some of which inhibit primary hemostasis All aspects of normal platelet function are affected Platelet function has previously been difficult to quantify but recently a novel test the platelet function analyzer PFA-100 has been determined to be both sensitive and specific in assessing platelet function Conventional hemodialysis CHD has been shown to partially correct thrombocytopathy Enhanced uremic clearance can now be attained through the use of short daily hemodialysis SDHD Cardiovascular disease is the most common cause of mortality in dialysis patients accounting for 40 of deaths Volume overload is associated with high blood pressure left ventricular hypertrophy and elevated markers of inflammation and these factors have been associated with increased cardiovascular mortality SDHD has been shown to control blood pressure and limit volume expansion Pulse wave velocity PWV has been used to assess arterial compliance and reduction of arterial elasticity of large and small arteries which have been associated with cardiovascular outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None