Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00188058
Status:
COMPLETED
Last Update Posted:
2019-03-22
First Post:
2005-09-12
Brief Title:
Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Sponsor:
University Hospital Angers
Organization:
University Hospital Angers
Study Overview
Official Title:
Comparison of Two Strategies for Setting Positive End-Expiratory Pressure in Acute Lung Injury Acute Respiratory Distress Syndrome ExPress Study
Status:
COMPLETED
Status Verified Date:
2019-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ExPress
Brief Summary:
The aim of this multicenter randomized controlled trial is to compare the impact on mortality of patients mechanically ventilated for acute lung injury or acute respiratory distress syndrome of two strategies for setting end-expiratory pressure
Detailed Description:
Most patients suffering from acute lung injury or acute respiratory distress syndrome require mechanical ventilation In this setting positive end-expiratory pressure is used to improve arterial oxygenation While the beneficial effect on clinical outcome of using low tidal volume is clearly proven the best way to titrate PEEP is not known Higher PEEP levels may better improve oxygenation and reduce ventilator-induced lung injury by reducing end-expiratory alveolar collapse but may also cause circulatory depression and aggravate lung injury from end-inspiratory overdistension This trial compares the impact on outcome of two strategies for setting PEEP In the minimal alveolar distension arm PEEP is set for a total PEEP PEEP intrinsic PEEP between 5 and 9 cm H20 In the maximal alveolar recruitment arm PEEP is set for a plateau pressure between 28 and 30 cm H20 A tidal volume of 6 mlkg predicted body weight is used in the two arms The goals for arterial oxygenation and PaCO2 are the same in the two arms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DGS 2002 - 0381 | None | None | None |